{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:35Z","timestamp":1789609235955,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold>: In patients suffering from dilated cardiomyopathy (DCM), immunoadsorption with subsequent IgG substitution (IA\/IgG) leads to an acute and prolonged improvement of hemodynamics and heart failure symptoms. However, some patients receiving IA\/IgG experience recurrence of heart failure after an initial benefit. The aim of this study was to investigate whether a second IA\/IgG treatment episode improves left ventricular systolic function and further mitigates heart failure symptoms in these patients. <jats:bold>Methods<\/jats:bold>: We retrospectively analyzed 15 DCM patients who experienced a significant improvement of LVEF (\u2265 5% absolute or\u2009\u2265\u200920% relative) and heart failure symptoms (\u2265 1 NYHA functional class) but a subsequent deterioration (decline in LVEF\u2009\u2265\u20095% absolute or\u2009\u2265\u200920% relative and NYHA worsening \u22651 class) after the first IA\/IgG. These patients underwent a second IA\/IgG treatment 41.7\u2009\u00b1\u200927.4 months after the first cycle. Follow up data were acquired 3\u20136 months after both IA\/IgG treatments. <jats:bold>Results<\/jats:bold>: The first IA\/IgG induced an improvement of LVEF from 33\u2009\u00b1\u20096.4% to 43.2\u2009\u00b1\u20097.9% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and of mean NYHA functional class from 2.9\u2009\u00b1\u20090.26 to 1.8\u2009\u00b1\u20090.56 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The second treatment was associated with a significant improvement in LVEF (from 29.7\u2009\u00b1\u20094.6% to 34.9\u2009\u00b1\u20098.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.013) and NYHA functional class (2.87\u2009\u00b1\u20090.64 to 2.33\u2009\u00b1\u20090.72; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). This improvement was less pronounced compared to the first treatment with respect to both, LVEF (<jats:italic>P<\/jats:italic>\u2009=\u20090.09) and NYHA improvement (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). <jats:bold>Conclusion:<\/jats:bold> In DCM patients, who experience a significant improvement of LVEF and heart failure symptoms after IA\/IgG but a subsequent relapse during follow up, repeated IA\/IgG may be considered. J. Clin. Apheresis 30:217\u2013223, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21364","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T09:15:15Z","timestamp":1414401315000},"page":"217-223","source":"Crossref","is-referenced-by-count":16,"title":["The effect of a repeated immunoadsorption in patients with dilated cardiomyopathy after recurrence of severe heart failure symptoms"],"prefix":"10.1002","volume":"30","author":[{"given":"Markus","family":"Reinthaler","sequence":"first","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Empen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars R.","family":"Herda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schwabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan B.","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Greifswald  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14283-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.628"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.5.649"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.01.060"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.1.97"},{"key":"e_1_2_7_8_1","first-page":"35","article-title":"Clinical implications of anti\u2010heart autoantibodies in myocarditis and dilated cardiomyopathy","volume":"41","author":"Caforio AP","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2681"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036746.49449.64"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.055"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs330"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.8.1994"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.12.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs123"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0162-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0287-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02314.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.06.027"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.6.1686"},{"key":"e_1_2_7_22_1","first-page":"268","volume-title":"Clinical exercise testing","author":"Jones N","year":"1988"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.448"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00568-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.606509"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90256-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.01.012"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21364","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:13:15Z","timestamp":1696612395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,27]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/jca.21364"],"URL":"https:\/\/doi.org\/10.1002\/jca.21364","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,27]]}}}