{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:56Z","timestamp":1789025036581,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Fetal anemia is caused by Rhesus (RhD) sensitization as a result of RhD incompatibility during pregnancy. The severe form of this disease can cause hydrops fetalis leading to intrauterine death. We experienced a highly sensitized 39\u2010year\u2010old woman with B Rh\u2010negative blood. She had a history of three induced abortions and experienced perinatal death associated with hydrops fetalis. During the pregnancy prior to her most recent one, she was treated with double\u2010filtration plasmapheresis (DFPP), high dose \u03b3\u2010globulin and intrauterine fetal blood transfusion (IUT). For her most recent pregnancy, we performed only weekly or fortnightly DFPP from 13 weeks until delivery. Anti\u2010D antibody titer was maintained between 32 and 256 without any signs of fetal anemia. IUT was not required at any stage of the pregnancy. No adverse events were observed. She successfully delivered a healthy male infant weighing 2,289 g by Cesarean section at 35 weeks. Repeated DFPP may be an effective and safe strategy to reduce antibody titers in highly sensitized women with RhD\u2010incompatible pregnancy, avoiding the need for IUT. J. Clin. Apheresis 30:305\u2013307, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21372","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T06:42:35Z","timestamp":1416552155000},"page":"305-307","source":"Crossref","is-referenced-by-count":13,"title":["Successful treatment of severe rhesus D\u2010incompatible pregnancy with repeated double\u2010filtration plasmapheresis"],"prefix":"10.1002","volume":"30","author":[{"given":"Koichi","family":"Kamei","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development, 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development, 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development, 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology National Center for Child Health and Development, 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Okada","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development 2\u201010\u20101, Okura Setagaya\u2010ku Tokyo 157\u20108535 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31817d453c"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2012-0093"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20288"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2006.00393.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073192"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90661-L"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.063"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:55:50Z","timestamp":1696362950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/jca.21372"],"URL":"https:\/\/doi.org\/10.1002\/jca.21372","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}