{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:14Z","timestamp":1789609214991,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:00:00Z","timestamp":1432339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Reflex sympathetic dystrophy, also known as complex regional pain syndrome (CRPS), has recently been shown to be associated with autoantibodies against \u03b22\u2010adrenergic and muscarinic M2 receptors. In addition to pain and sudomotor\/vasomotor symptoms, dysautonomia is also observed in a subset of CRPS patients. Despite its severity, there are few effective therapies for CRPS described to date. We report a case of a 14\u2010year\u2010old girl with CRPS of her right leg and dysautonomia (gastroparesis, postural tachycardia) refractory to multiple therapies, successfully treated with therapeutic plasma exchange (TPE) with albumin replacement. The patient, who has serum anti \u03b22\u2010adrenergic and muscarinic M2 receptor autoantibodies in addition to nicotinic acetylcholine receptor ganglionic autoantibodies, underwent an initial course of five TPEs over a 2\u2010week period. She demonstrated a clinical response to TPE as manifested by a rapid improvement in her fatigue and gastroparesis, with a gradual yet significant improvement in her leg pain and sudomotor\/vasomotor flares. Following the loading procedures, the patient was treated with rituximab. She continues to require periodic TPE to maintain a remission, with additional immunosuppression being considered long term. Although further studies are needed, TPE (in combination with immunosuppression) may be an appropriate therapy for CRPS patients with detectable autoantibodies, as it is for better characterized diseases with autoantibodies against neuronal surface receptors such as myasthenia gravis or Lambert Eaton myasthenic syndrome. J. Clin. Apheresis 31:368\u2013374, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jca.21407","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T04:44:30Z","timestamp":1432529070000},"page":"368-374","source":"Crossref","is-referenced-by-count":30,"title":["Complex regional pain syndrome and dysautonomia in a 14\u2010year\u2010old girl responsive to therapeutic plasma exchange"],"prefix":"10.1002","volume":"31","author":[{"given":"Jeanne E.","family":"Hendrickson","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine New Haven Connecticut"},{"name":"Department of Pediatrics Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma T.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Adams School Guilford Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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