{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:16Z","timestamp":1789609216374,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic plasma exchange (TPE) and double plasma molecular absorption system (DPMAS) were two extracorporeal liver support systems. Few studies compared their efficacy profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was to compare the efficacy of TPE and DPMAS on acute\u2010on\u2010chronic liver failure (ACLF) caused by hepatitis B virus (HBV\u2010ACLF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>60 HBV\u2010ACLF patients were enrolled and prospectively studied. All patients received entecavir therapy, and were assigned to TPE group (<jats:italic>n<\/jats:italic>\u2009=\u200933) and DPMAS group (<jats:italic>n<\/jats:italic>\u2009=\u200927). Primary end\u2010points were the effects of TPE and DPMAS on liver function and serum inflammatory markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum procalcitonin, interleukin (IL)\u22126, and high sensitive C\u2010reactive protein (hsCRP) were significantly elevated in patients with HBV\u2010ACLF. TPE achieved significantly higher removal rates of total bilirubin (TBIL, <jats:italic>P<\/jats:italic>\u2009=\u2009.002), direct bilirubin (DBIL, <jats:italic>P<\/jats:italic>\u2009=\u2009.006), and hsCRP (<jats:italic>P<\/jats:italic>\u2009=\u2009.010) than DPMAS, but DPMAS displayed lower loss rate of albumin (<jats:italic>P<\/jats:italic>\u2009=\u2009.000). TPE and DPMAS resulted in similarly increased serum IL\u20106 levels and comparable 12\u2010week survivals (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). Multivariate analysis showed that hospital stay (Relative Risk [RR]: 1.062, 95% Confidence Interval [CI]: 1.011\u20101.115, <jats:italic>P<\/jats:italic>\u2009=\u2009.016), prothrombin time (RR: 1.346, 95% CI: 1.077\u20101.726, <jats:italic>P<\/jats:italic>\u2009=\u2009.010), and international normalized ratio (RR: 0.013, 95% CI: 0.006\u20100.788, <jats:italic>P<\/jats:italic>\u2009=\u2009.041) were independent predictors for 12\u2010week survival. Both TPE and DPMAS treatments were well\u2010tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to DPMAS, TPE was more efficient in eliminating TBIL, DBIL, and hsCRP, but it was associated with higher loss rate of albumin. TPE and DPMAS were similar in improving 12\u2010week survivals in HBV\u2010ACLF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21535","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T11:46:08Z","timestamp":1489751168000},"page":"453-461","source":"Crossref","is-referenced-by-count":56,"title":["Therapeutic plasma exchange versus double plasma molecular absorption system in hepatitis B virus\u2010infected acute\u2010on\u2010chronic liver failure treated by entercavir: A prospective study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-922X","authenticated-orcid":false,"given":"Yue\u2010Meng","family":"Wan","sequence":"first","affiliation":[{"name":"Gastroenterology Department II or Hepatology Center The Second Affiliated Hospital of Kunming Medical University Kunming City 650101 Yunnan Province China"},{"name":"Graduate Department of Kunming Medical University Kunming City 650500 Yunnan Province 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