{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:23:42Z","timestamp":1788485022972,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In ulcerative colitis (UC) patients, cytapheresis depletes elevated and activated leucocytes, which are known to release inflammatory cytokines including tumor necrosis factor (TNF)\u2010\u03b1. Further, there are UC patients who develop erythema nodosum (EN) or pyoderma gangrenosum (PG) as extra\u2010intestinal manifestations of UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2008 and 2015, 181 consecutive patients with active UC received cytapheresis with either a granulocyte and monocyte apheresis (GMA) column or with a leucocyte removal filter (LCAP) as remission induction therapy. Each patient received weekly or intensive (2\u20103 sessions\/week) cytapheresis up to 10 sessions. In 13 patients, UC was complicated by EN or PG. Lichtiger's clinical activity index (CAI) \u22644 meant remission, while \u22653 decrease in CAI meant response to therapy. Prednisolone sparing and the changes in the extra\u2010intestinal manifestations were factored for assessing treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall remission and response rates were 52.5% and 71.8%, respectively, CAI fell from 9.4\u2009\u00b1\u20093.3 to 4.9\u2009\u00b1\u20093.5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The efficacy rates in subgroups on concomitant corticosteroid, anti\u2010TNF or tacrolimus, and those without concomitant medications were not significantly different (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). However, in 84 patients on prednisolone, the average daily prednisolone dose was reduced from 18.15 to 12.43 mg\/day (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with 21.7% being corticosteroid free. All patients with EN or PG showed favorable response to cytapheresis, notably 2 EN patients achieving remission after just 2 cytapheresis sessions without concomitant medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective efficacy evaluation, cytapheresis was effective as remission induction therapy with steroid sparing effect and desirable safety profile. Further, patients with EN or PG responded favorably to cytapheresis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21555","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T09:46:40Z","timestamp":1496656000000},"page":"21-28","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of cytapheresis for remission induction and dermatological manifestations of ulcerative colitis"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-4209","authenticated-orcid":false,"given":"Osamu","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo 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