{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:03Z","timestamp":1786977963177,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Macrophage activation syndrome (MAS) is a life\u2010threating complication of systemic juvenile idiopathic arthritis (s\u2010JIA). Steroid and cyclosporine (CsA) are effective for MAS, but, treatment for steroid\u2010 and CsA\u2010resistant patients is still challenging. We report the case of steroid and CsA resistant s\u2010JIA associated MAS misdiagnosed as Kawasaki disease (KD), who was successfully treated with the combination of plasma exchange (PE) and leukocytapheresis (LCAP) followed by plasma diafiltration (PDF). PE\u2009+\u2009LCAP effectively removed proinflammatory cytokines and reduced the number of peripheral white blood cells. Furthermore, PDF also removed proinflammatory cytokines as effectively as PE\u2009+\u2009LCAP. Early diagnosis of s\u2010JIA is necessary to avoid developing MAS. The measurement of serum ferritin and IL\u201018 levels are useful for differentiating s\u2010JIA from KD. Apheresis therapies are an alternative option to induce remission for severe patients with steroid\u2010 or CsA\u2010resistant MAS.<\/jats:p>","DOI":"10.1002\/jca.21570","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T05:02:43Z","timestamp":1500613363000},"page":"117-120","source":"Crossref","is-referenced-by-count":26,"title":["Role of plasma exchange, leukocytapheresis, and plasma diafiltration in management of refractory macrophage activation syndrome"],"prefix":"10.1002","volume":"33","author":[{"given":"Noriko","family":"Kinjo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine University of the Ryukyus Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine University of the Ryukyus Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Center University of the Ryukyus Hospital Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-7772","authenticated-orcid":false,"given":"Masaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.5.421"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.112.6.e495","article-title":"Are children with Kawasaki disease and prolonged fever at risk for macrophage activation syndrome?","volume":"112","author":"Muise A","year":"2003","journal-title":"Pediatrics."},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200209000-00012"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.11.1285"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11256"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2093-5"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00969.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00864.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00595.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2007.00505.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2182"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.6.1379"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1630-3"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2016.1159120"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3059-2"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-009-0164-2"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T05:51:42Z","timestamp":1695534702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jca.21570"],"URL":"https:\/\/doi.org\/10.1002\/jca.21570","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}