{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:07:06Z","timestamp":1740103626014,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:00:00Z","timestamp":1502496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet donors receive 40 mmol or more of IV citrate anion during donation. When plasma ionized calcium ([Ca<jats:sup>2+<\/jats:sup>]) falls by \u223c20%, half of the donors report symptoms of hypocalcemic toxicity. Citrus juices contain clinically relevant amounts of citrate anion. We asked whether citrus juice can lower [Ca<jats:sup>2+<\/jats:sup>] thus potentially contributing to hypocalcemic toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Six volunteers were given 20.4 mmol of citrate anion as grapefruit juice or orange juice. Capillary blood obtained by fingerstick was analyzed for [Ca<jats:sup>2+<\/jats:sup>] using an iSTAT point\u2010of\u2010care blood analyzer. [Ca<jats:sup>2+<\/jats:sup>] was measured at baseline and then 30, 60, 120, and 180 minutes after drinking juice. Subjects were tested with the alternative juice on a subsequent day. The outcome measure was the percent change in plasma [Ca<jats:sup>2+<\/jats:sup>] from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>[Ca<jats:sup>2+<\/jats:sup>] fell \u22122.2% to \u221211.5% in four of six subjects 30 minutes after drinking grapefruit juice. The effect persisted up to 3 hours. [Ca<jats:sup>2+<\/jats:sup>] fell \u22122.1% to \u221212.2% in four of six subjects 30\u201060 minutes after drinking orange juice. The effect abated after 2 hours. We could not correlate gender or body surface area to these findings.<\/jats:p><jats:p><jats:bold>Summary and Conclusions<\/jats:bold>: Citrus juice may lower [Ca<jats:sup>2+<\/jats:sup>] for 2\u20103 hours. This could add to the effect of IV citrate infusion during platelet donation, thus worsening the expected fall in [Ca<jats:sup>2+<\/jats:sup>]. This, in turn, would likely increase the rate and severity of hypocalcemic toxicity. It is prudent to advise platelet donors to avoid high citrate anion beverages, such as citrus juice, for at least 4 hours prior to donation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21575","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T10:12:44Z","timestamp":1502532764000},"page":"222-225","source":"Crossref","is-referenced-by-count":4,"title":["Dietary citrate and plasma ionized calcium: Implications for platelet donors"],"prefix":"10.1002","volume":"33","author":[{"given":"Stefanie","family":"Haynes","sequence":"first","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elda","family":"Hickson","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Linden","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"St. Pierre","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Sulmasy","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Welch","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"},{"name":"Division of Transfusion Medicine University of Mass Memorial Medical Center Worcester Massachusetts"},{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"},{"name":"Department of Pathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy","family":"Greene","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Vauthrin","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-8401","authenticated-orcid":false,"given":"Robert","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Apheresis Service UMass Memorial Medical Center Worcester Massachusetts"},{"name":"Division of Transfusion Medicine University of Mass Memorial Medical Center Worcester Massachusetts"},{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"},{"name":"Department of Pathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"New York Blood Center: For a better donation experience. 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