{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:04:54Z","timestamp":1756382694650,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital factor XI (FXI) deficiency is associated with a variable bleeding phenotype. Recent reports have documented the use of therapeutic plasma exchange to rapidly and isovolumetrically increase FXI levels before invasive procedures in patients with congenital FXI deficiency.<\/jats:p><jats:p>We report a case of acquired FXI deficiency in a pregnant woman with lupus. We proved that the inhibitor was an IgG, therefore potentially capable of crossing the placenta. While immune suppression eliminated detectable circulating inhibitor, the woman's FXI remained quite low. A multi\u2010disciplinary team was formed and therapeutic plasma exchange with 100% plasma replacement was performed when the patient went into labor, to acutely raise her FXI level and remove any potential non\u2010neutralizing inhibitor. The mother had a controllable level of bleeding during post\u2010TPE cesarean section; the baby had no bleeding and the baby's FXI levels were not overtly abnormal.<\/jats:p><jats:p>Therapeutic plasma exchange in acquired FXI deficiency (or other acquired hemophilias) can both acutely isovolumetrically raise factor levels and remove any circulating inhibitor.<\/jats:p>","DOI":"10.1002\/jca.21593","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T06:36:41Z","timestamp":1507876601000},"page":"427-430","source":"Crossref","is-referenced-by-count":8,"title":["Acquired factor <scp>XI<\/scp> deficiency and therapeutic plasma exchange"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-2905","authenticated-orcid":false,"given":"Geoffrey D.","family":"Wool","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Treml","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"1","article-title":"Therapeutic plasma exchange for perioperative management of patients with congenital factor XI deficiency","author":"Alsammak MS","year":"2017","journal-title":"J Clin Apher"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21442"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00385.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.03.005"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30074-9"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01462.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70132-X"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-5908-0.00040-5"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-10-0668"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830350210"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01314.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01677.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029608327864"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340903144238"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03395.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14592"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1651.1651"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23287"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14132"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21470_c"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:33:04Z","timestamp":1694993584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,13]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/jca.21593"],"URL":"https:\/\/doi.org\/10.1002\/jca.21593","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"type":"print","value":"0733-2459"},{"type":"electronic","value":"1098-1101"}],"subject":[],"published":{"date-parts":[[2017,10,13]]}}}