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Often the disease processes where apheresis plays a role in treatment are considered \u201corphan diseases\u201d\u2014relatively rare disease processes that lack specific pharmaceutical agents or established treatment protocols. Many of these disease processes can affect the eye with devastating results for the eyesight of these patients. The unique ability of apheresis to affect disease by modifying blood plasma and modulating disease\u2010causing agents therein renders apheresis procedures valuable tools in the treatment of certain ophthalmologic diseases. This review comprehensively evaluates the role of apheresis in the treatment of ophthalmologic diseases of the eye and surrounding orbit including age\u2010related macular degeneration, bilateral diffuse uveal melanocytic proliferation, paraneoplastic retinopathy, atopic keratoconjunctivitis, sympathetic ophthalmia, and endocrine\u2010associated ophthalmopathy. Apheresis procedure parameters are provided for the apheresis practitioner based on review of the relevant literature.<\/jats:p>","DOI":"10.1002\/jca.21607","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T09:36:47Z","timestamp":1510997807000},"page":"380-392","source":"Crossref","is-referenced-by-count":8,"title":["Seeing is believing: A review of apheresis therapy in the treatment of ophthalmologic disease"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-377X","authenticated-orcid":false,"given":"Brendan C.","family":"Graham","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose S.","family":"Pulido","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Mayo Clinic Rochester 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