{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:49:29Z","timestamp":1792021769575,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Performing therapeutic plasma exchange (TPE) with albumin replacement decreases coagulation factor and platelet levels. No defined guidelines exist regarding laboratory testing to assess hemostasis in patients undergoing TPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A survey to evaluate hemostasis testing with TPE was distributed using online survey software. One response per institution was analyzed based on a hierarchical algorithm, excluding membrane filtration users, resulting in a maximum of 120 respondents per question. Descriptive analysis was performed with results reported as the number and\/or frequency (%) of respondents to each question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The practices represented vary by institution type, number of apheresis procedures per year, and performance of TPE on children. Prior to TPE planned with albumin replacement, many respondents obtain laboratory studies for almost all patients (54.9% outpatients and 68.7% inpatients); however, some do not routinely obtain laboratory studies (9.7% outpatients and 4.4% inpatients). Hemoglobin\/hematocrit, platelet count, fibrinogen, partial thromboplastin time (aPTT), and international normalized ratio (INR) are obtained prior to all TPE by 62.5%, 53.4%, 31.0%, 18.1%, and 17.7% of respondents, respectively; however, 1.0%, 8.7%, 29.0%, 38.3%, and 35.4%, respectively, do not routinely obtain these studies. Variation was observed in laboratory threshold values for action; the most common reported were hemoglobin\/hematocrit &lt;7 g\/dL or 21% (31.0%), platelet count &lt;50\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (24.1%), fibrinogen &lt;100\u2009mg\/dL (65.3%), aPTT\u2009&gt;reference range and &gt;1.5 times reference range (tied, 28.1%), and INR &gt;1.5 (20.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Practice variation exists in hemostasis laboratory testing and threshold values for action with TPE. Further studies are needed to determine optimal hemostasis testing strategies with TPE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21666","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T13:22:44Z","timestamp":1540905764000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hemostasis testing and therapeutic plasma exchange: Results of a practice survey"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5776-6400","authenticated-orcid":false,"given":"Nicole D.","family":"Zantek","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica B.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian A.","family":"Rollins\u2010Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Division University of Pittsburgh Medical Center Presbyterian\u2010Shadyside Hospital  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Crane","sequence":"additional","affiliation":[{"name":"LifeSource Blood Center  Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard I.","family":"Boral","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kentucky  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York University  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika M.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Consultant  Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-2385","authenticated-orcid":false,"given":"Chisa","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-4349","authenticated-orcid":false,"given":"Yanyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Bloodworks  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C. C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Coagulation Quest Diagnostics Nichols Institute  Virginia"},{"name":"Departments of Pediatrics and Pathology George Washington School of Medicine and Health Sciences  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1982.22182154218.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920030209"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(02)00093-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1979.19580059816.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1979.tb01172.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.00627.x"},{"key":"e_1_2_8_8_1","first-page":"13","volume-title":"Therapeutic Hemapheresis: A Technical Workshop","author":"Chopek M","year":"1980"},{"key":"e_1_2_8_9_1","first-page":"147","article-title":"Coagulation disorders with plasma exchange","volume":"3","author":"Simon TL","year":"1982","journal-title":"Plasma Ther Transfus Technol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24484275577.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26286152905.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920090312"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V56.6.1055.1055"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.3.694.694"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21294"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21441"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.01.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130402"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21653"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.7.3797920"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21301"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21592"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920090102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20143"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00546.x"},{"key":"e_1_2_8_26_1","first-page":"1","volume-title":"Transfusion Therapy: Clinical Principles and Practice","author":"Callum JL","year":"2011"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.09.021"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx054"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078962"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.6.550"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1104540"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.4.447"},{"issue":"4","key":"e_1_2_8_33_1","first-page":"671","article-title":"Discard volumes necessary for clinically useful coagulation studies from heparinized Hickman catheters","volume":"23","author":"Mayo DJ","year":"1996","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1188\/02.ONF.E26-E34"},{"key":"e_1_2_8_35_1","unstructured":"ABIMFoundation. Choosing Wisely [Accessed May 8 2018].http:\/\/www.choosingwisely.org\/clinician-lists."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12347"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:57:53Z","timestamp":1694671073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/jca.21666"],"URL":"https:\/\/doi.org\/10.1002\/jca.21666","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]},"assertion":[{"value":"2017-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}