{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:18:21Z","timestamp":1747149501293,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>\nIntroduction:<\/jats:bold> Red blood cells exchange transfusion has been demonstrated to be helpful in treatment of sever P. falciparum<\/jats:italic><\/jats:styled-content> malaria. However, no large scale randomized controlled trials have been completed to date and the CDC does not recommend RBC exchange transfusions as standard of care. We present a case of severe cerebral malaria in a patient with extremely high parasitemia and severe altered mental status who improved rapidly with automated RBC exchange.<\/jats:p>\nReport:<\/jats:bold> Seventy\u2010two year old female presented with 1 day history of weakness, altered mental status, malaise, and cyclic sweats after returning from a trip to Sierra Leone. Thick and Thin Smears demonstrated P. falciparum<\/jats:italic><\/jats:styled-content> rings present and Quantitative malaria screen demonstrated 53.33% parasitemia. Patient was started on quinidine and doxycycline but continued to deteriorate. Automated RBC exchange transfusion was performed within 24\u2009hours of admission and resulted in rapid improvement in symptomology. Repeat thick and thin smears revealed undetectable parasite load.<\/jats:p>\nConclusion:<\/jats:bold> Automated RBC exchange may improve outcomes in severe P. falciparum<\/jats:italic><\/jats:styled-content> malaria when presenting parasite loads are very high.<\/jats:p>","DOI":"10.1002\/jca.21667","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T08:58:54Z","timestamp":1541149134000},"page":"61-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Red blood cell exchange in treatment of severe cerebral P. falciparum<\/i><\/scp> malaria: A case report"],"prefix":"10.1002","volume":"34","author":[{"given":"Joshua T.","family":"Genstler","sequence":"first","affiliation":[{"name":"Loma Linda University School of Medicine Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-1152","authenticated-orcid":false,"given":"Amir","family":"Abdipour","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Medical Director of Therapeutic Apheresis service Loma Linda University Medical Center Loma Linda California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"1","article-title":"Malaria surveillance \u2013 United States, 2014","volume":"66","author":"Cullen KA","year":"2017","journal-title":"MMWR Surveill Summ"},{"volume-title":"Management of Severe Malaria: A Practical Handbook","year":"2015","author":"World Health Organization","key":"e_1_2_4_3_1"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67176-0"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.3813"},{"key":"e_1_2_4_6_1","first-page":"CD005967","article-title":"Artesunate versus quinine for treating severe malaria","volume":"6","author":"Sinclair D","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-158"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.05.003"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14013"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/339810"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1264-z"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-115"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21470_c"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit429"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit662"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:58:01Z","timestamp":1694671081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/jca.21667"],"URL":"https:\/\/doi.org\/10.1002\/jca.21667","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"type":"print","value":"0733-2459"},{"type":"electronic","value":"1098-1101"}],"subject":[],"published":{"date-parts":[[2018,11,2]]},"assertion":[{"value":"2018-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}