{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:38Z","timestamp":1747149338063,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity has implications for hematopoietic progenitor cell (HPC) mobilization, chemotherapy administration, and medication dosing. We analyzed the impact of obesity on HPC mobilization as well as key outcomes that are associated with cell dose in autologous hematopoietic cell transplantation (AHCT) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study on 556 consecutive eligible AHCT recipients at our institution from 1\/2004 to 12\/2009. Patients were categorized into four groups based on the body mass index (BMI): underweight (BMI\u2009&lt;\u200918.5), normal (18.5\u201024.9), overweight (25.0\u201029.9), or obese (\u226530.0). Primary endpoints of interest included HPC mobilization, neutrophil and platelet recovery, hospital stay and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnoses were mostly non\u2010Hodgkin lymphoma, multiple myeloma, and Hodgkin lymphoma. The majority of the patients had received three or less prior chemotherapy regimens and had not received prior radiation therapy. Most patients had chemosensitive disease at time of transplant. For HPC mobilization regimen, 68% received chemotherapy and G\u2010CSF, 32% received G\u2010CSF alone. Busuflan\/etoposide\/cyclophosphamide, melphalan, and busulfan\/cyclophosphamide were used for conditioning. Obesity did not correlate with HPC mobilization and had no association with neutrophil or platelet recovery, or length of transplant hospitalization. On multivariable analysis, obese patients demonstrated better survival than those who were not obese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obese AHCT recipients had similar rates of HPC mobilization, neutrophil and platelet engraftment and length of transplant hospitalization, and experienced better survival compared with recipients with lower BMI. High BMI by itself should not be considered as a contraindication to AHCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21739","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T15:09:16Z","timestamp":1565017756000},"page":"638-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Body mass index does not impact hematopoietic progenitor cell mobilization for autologous hematopoietic cell transplantation"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-6528","authenticated-orcid":false,"given":"Jack","family":"Khouri","sequence":"first","affiliation":[{"name":"Blood &amp; Marrow Transplant Program Taussig Cancer Center, Cleveland Clinic  Cleveland Ohio"},{"name":"Therapeutic Apheresis Taussig Cancer Center, Cleveland Clinic  Cleveland 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