{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:54:34Z","timestamp":1788346474967,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effectiveness and safety of combining granulocyte\u2010monocyte apheresis (GMA) and vedolizumab (VDZ) in patients with refractory ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, multicentre pilot study included all UC patients receiving both GMA and VDZ. We recorded data on GMA sessions, demographic characteristics, and clinical response. Effectiveness was assessed 1 and 6 months after finishing the GMA using the partial Mayo score, C\u2010reactive protein, and fecal calprotectin levels. Data were also compiled on VDZ intensification, use of new immunomodulators and colectomy during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight patients were included (mean age 46\u2009years; 63% female; mean disease duration, 132\u2009months; 50% E3). GMA was started after a loss of response to VDZ in all cases (25% primary nonresponse and 75% secondary loss of response). All had previously received anti\u2010TNF agents. VDZ was prescribed as the second\u2010, third\u2010, or fourth\u2010line biologic in 37%, 50%, and 13% of cases, respectively. Patients had a mean baseline partial Mayo score of 7.5 (SD 2.1) and received a median of 15 GMA sessions (range 5\u201038). After a median follow\u2010up of 7.5 months (IQR 5\u201012), partial Mayo score decreased after 1 and 6 months (<jats:italic>P<\/jats:italic> = .01 and .06, respectively). Three patients (38%) achieved steroid\u2010free clinical remission and five (63%) withdrew VDZ. Colectomy rate was 38%. No adverse events were observed during the combination therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This small case series suggests that combining GMA with VDZ could be a treatment option in selected cases of UC with an inadequate response to this biologic agent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21746","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T14:09:02Z","timestamp":1568383742000},"page":"680-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The combination of granulocyte\u2010monocyte apheresis and vedolizumab: A new treatment option for ulcerative colitis?"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4578","authenticated-orcid":false,"given":"Iago","family":"Rodr\u00edguez\u2010Lago","sequence":"first","affiliation":[{"name":"Gastroenterology Department Hospital de Galdakao  Galdakao Spain"},{"name":"Biocruces Bizkaia Health Research Institute  Barakaldo Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"IMIBIC  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sempere","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital General Universitario de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-2308","authenticated-orcid":false,"given":"Esteban","family":"S\u00e1ez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Barreiro\u2010de Acosta","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Cl\u00ednico Universitario de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jone O.","family":"de Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Universitario de Basurto  Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Cabriada","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital de Galdakao  Galdakao Spain"},{"name":"Biocruces Bizkaia Health Research Institute  Barakaldo Vizcaya 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