{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:42Z","timestamp":1747149342438,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rh immune globulin (RhIG) may be administered to Rh(D)\u2010negative recipients of Rh(D)\u2010positive platelet (PLT) transfusions to mitigate anti\u2010D alloantibody formation. We report a series of seven patients in which anti\u2010C was detected as a result of RhIG administered as immunoprophylaxis following Rh\u2010mismatched apheresis PLT transfusion, persisting for a range of 27 to 167\u2009days post\u2010RhIG. The passively transferred anti\u2010C antibodies created complexities for subsequent transfusion support. Based on these challenges, in combination with emerging evidence supporting an extremely low anti\u2010D alloimmunization risk following Rh\u2010mismatched apheresis PLTs, we have changed our practice and now limit RhIG immunoprophylaxis in this setting to women of reproductive age. In summary, the blood bank and apheresis communities should be aware that passive transfer of non\u2010D antibodies is possible following RhIG administration. This phenomenon represents a compelling reason to consider the risk\/benefit ratio of RhIG and to limit its use to situations in which it is clinically necessary.<\/jats:p>","DOI":"10.1002\/jca.21773","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T17:48:08Z","timestamp":1582912088000},"page":"224-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Passive anti\u2010C acquired in the setting of Rh immune globulin administration following Rh mismatched apheresis platelet transfusion: A case series"],"prefix":"10.1002","volume":"35","author":[{"given":"Nataliya","family":"Sostin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raisa","family":"Balbuena\u2010Merle","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Pathology &amp; Laboratory Medicine Service VA Connecticut Healthcare System  West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-2245","authenticated-orcid":false,"given":"Christopher A.","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Pathology &amp; Laboratory Medicine Service VA Connecticut Healthcare System  West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(79)90009-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02953.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12341"},{"volume-title":"Technical Manual","year":"2017","author":"Delaney M","key":"e_1_2_5_5_1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050551.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14614"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000185"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.21773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.21773","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:17:30Z","timestamp":1694006250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/jca.21773"],"URL":"https:\/\/doi.org\/10.1002\/jca.21773","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"type":"print","value":"0733-2459"},{"type":"electronic","value":"1098-1101"}],"subject":[],"published":{"date-parts":[[2020,2,28]]},"assertion":[{"value":"2019-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}