{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:44Z","timestamp":1747149344683,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autologous stem cell transplantation (auto\u2010SCT) is a treatment approach in non\u2010Hodgkin lymphoma (NHL) patients. The options for mobilization of CD34<jats:sup>+<\/jats:sup> cells to support high\u2010dose therapy are granulocyte\u2010colony stimulating factors (G\u2010CSFs) alone or after chemotherapy. Limited data exist on the efficacy of lipegfilgrastim (LIPEG) in the mobilization field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The present prospective nonrandomized study compared LIPEG 6 mg (n = 40) with pegfilgrastim (PEG) 6\u2009mg (n = 37) in the mobilization of blood CD34<jats:sup>+<\/jats:sup> cells after chemotherapy in NHL patients with comparable mobilizing chemotherapy and disease status before auto\u2010SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly higher blood CD34<jats:sup>+<\/jats:sup> cell (B\u2010CD34<jats:sup>+<\/jats:sup>) counts were observed in the LIPEG group at the start of the first apheresis (44 vs 23\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/L, <jats:italic>P<\/jats:italic> = .009), in line with a higher collection yield of the first apheresis (3.3 vs 2.1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg, <jats:italic>P<\/jats:italic> = .086) and total yield of CD34<jats:sup>+<\/jats:sup> cells (4.7 vs 2.9\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg, <jats:italic>P<\/jats:italic> = .004). LIPEG proved to be a more effective G\u2010CSF, resulting in a higher B\u2010CD34<jats:sup>+<\/jats:sup> cell peak (60 vs 32\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/L, <jats:italic>P<\/jats:italic> = .030) and higher proportion of excellent mobilizers (33% vs 8%, <jats:italic>P<\/jats:italic> = .008). The superiority of LIPEG was confirmed in the multivarite analysis concerning the CD34<jats:sup>+<\/jats:sup> cell yield of the first apheresis day (<jats:italic>P<\/jats:italic> = .010) and the total yield (<jats:italic>P<\/jats:italic> = .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mobilization of blood grafts with LIPEG added to chemotherapy was associated with higher CD34<jats:sup>+<\/jats:sup> cell apheresis yields than with PEG. A randomized study is warranted to verify these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21785","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T22:33:07Z","timestamp":1587421987000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective comparison of pegfilgrastim and lipegfilgrastim combined with chemotherapy in the mobilization of <scp>CD34<\/scp><sup>+<\/sup> cells in <scp>NHL<\/scp> patients"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-2582","authenticated-orcid":false,"given":"Anu","family":"Partanen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio University 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