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Antibodies against melanoma differentiation\u2010associated gene 5 (MDA\u20105) are often found in patients with CADM. We report a patient with advanced CADM with ILD and MDA\u20105 antibodies who failed to improve with immunosuppressants. We performed 2 TPE over 3\u2009days, using 5% albumin as replacement fluid. Although five total TPE were planned, he was transferred for lung transplant evaluation after the second TPE; he died 16\u2009days after transfer without receiving a transplant. A literature review identified four patients with CADM and MDA\u20105 antibodies treated with TPE; all experienced symptomatic improvement of their ILD. We attribute our patient's outcome to the advanced nature of his disease rather than a failure of TPE. Additional research may indicate a possible reclassification of CADM with MDA\u20105 antibodies in future ASFA guidelines.<\/jats:p>","DOI":"10.1002\/jca.21815","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T19:57:47Z","timestamp":1595102267000},"page":"483-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of therapeutic plasma exchange in clinically amyopathic dermatomyositis with <scp>MDA<\/scp>\u20105 antibody: A case report and review of the literature"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-6849","authenticated-orcid":false,"given":"Alexander","family":"Fine","sequence":"first","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie 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