{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:07:53Z","timestamp":1774998473687,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with clinically amyopathic dermatomyositis (CADM) with anti\u2010melanoma differentiation\u2010associated gene 5 antibody (anti\u2010MDA5 Ab) frequently develop rapidly progressive interstitial pneumonia (RPIP), often with fatal outcomes. Therapeutic plasma exchange (TPE) has been reported as effective against CADM\u2010RPIP refractory to conventional immunosuppressive therapy. However, the detailed mechanisms by which TPE improves disease activity of CADM\u2010RPIP remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To elucidate the clinical and demographic characteristics of patients with anti\u2010MDA5 Ab\u2010positive CADM\u2010RPIP treated with TPE and to analyze changes in laboratory findings before, during, and after TPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Patients hospitalized for CADM\u2010RPIP and treated with TPE in 2017 and 2018 were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients were successfully treated with TPE, with good tolerance. Anti\u2010MDA5 Ab titers decreased significantly over the course of TPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We emphasize that TPE could represent an effective treatment option for CADM\u2010RPIP refractory to traditional therapy. Removal of anti\u2010MDA5 Ab and other pathogenic factors may facilitate favorable outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21824","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T21:20:21Z","timestamp":1598563221000},"page":"435-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic plasma exchange for clinically amyopathic dermatomyositis (<scp>CADM<\/scp>) associated with rapidly progressive interstitial pneumonia"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-7152","authenticated-orcid":false,"given":"Akira","family":"Yamagata","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Ohara Healthcare Foundation Kurashiki Central Hospital  Okayama 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