{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:17:22Z","timestamp":1763018242619,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Extracorporeal photopheresis (ECP) is a procedure used to influence T\u2010cell activity in patients suffering from immune\u2010mediated cellular damage secondary to activated lymphocytes. Although well\u2010tolerated, iron deficiency anemia (IDA) has been described. The goal herein is to describe IDA in patients who received extracorporeal photopheresis (ECP) treatment using UVAR (Therakos Inc) and CELLEX (Therakos Inc) instruments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Patients treated with ECP from 2015 to 2019 were retrospectively analyzed. IDA was defined by a decrease in hemoglobin following treatment with concomitant decrease in mean cell volume, mean corpuscular hemoglobin concentration, increased RBC distribution width, and\/or iron studies compatible with IDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the four\u2010year study period, thirty\u2010four patients received ECP. Thirteen (38%) underwent treatment with the previous UVAR device while 21 (62%) received treatment on the newer CELLEX instrument. Nineteen (56%) of the cohort developed clinical and laboratory evidence of IDA with an average of 3.2\u2009g\/dL decrease in hemoglobin. Patients who developed IDA treated on the CELLEX instrument experienced a significantly greater drop in hemoglobin (<jats:italic>P<\/jats:italic> = .04) than those treated on the UVAR. Examining the CELLEX\u2010treated patients, those who received the procedure at greater frequency experienced significantly greater drops in hemoglobin (<jats:italic>P<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IDA is a risk of chronic ECP therapy and is likely secondary to retained blood components in the instrument. The temporal relationship between anemia and ECP treatment has a direct correlation with the treatment schedule. Patients undergoing ECP treatment should be closely monitored for the development of IDA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21836","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T14:30:03Z","timestamp":1601044203000},"page":"34-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of iron deficiency anemia in patients undergoing extracorporeal photopheresis: Comparison of the <scp>UVAR<\/scp> and <scp>CELLEX<\/scp> instruments"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-1073","authenticated-orcid":false,"given":"Mitchell M.","family":"Moosavi","sequence":"first","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail L.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Duncan","sequence":"additional","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean R.","family":"Stowell","sequence":"additional","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund K.","family":"Waller","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Program, Department of Hematology and Oncology Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Roback","sequence":"additional","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Center for Cellular Therapy and Transfusion, Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90119-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0266-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.06.035"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02712.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.038"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000765"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmy034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21740"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12504"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21744"}],"container-title":["Journal 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