{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:21:21Z","timestamp":1778613681431,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collection of a large number of early hematopoietic progenitors is essential for allogeneic apheresis products intended for TCR\u2010alpha\/beta depletion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We added plerixafor 0.24\u2009mg\/kg body weight (bw) on day 4 of high\u2010dose filgrastim mobilization 10\u00a0hours prior to apheresis in 16 (30.5%) pediatric allogeneic donors who failed to recover a sufficient number of CD34+ cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On day 4 of G\u2010CSF, the median CD34+ cell count in peripheral blood was 6 per \u03bcL (range 4\u20109 per \u03bcL) in 6 poor mobilizers and 16 per \u03bcL (range 12\u201019 per \u03bcL) in insufficient mobilizers. In all donors, the threshold of 50 CD34+ cells\/\u03bcL was achieved, and the median increase was 14.8\u2010fold in poor mobilizers and 6.5\u2010fold in insufficient mobilizers, whereas it was 3.45\u2010fold increase in those mobilized with G\u2010CSF alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In all donors, a predefined number of &gt;10\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34+ cells\/kg of recipient bw before depletion was reached in the apheresis product. The use of plerixafor did not affect the purity of further TCR\u2010alpha\/beta depletion. Side effects were mild to moderate and consisted of nausea and vomiting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, the safety and high efficacy of plerixafor was proven in healthy pediatric allogeneic hematopoietic cell donors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21891","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:51:38Z","timestamp":1615207898000},"page":"547-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plerixafor added to <scp>G\u2010CSF<\/scp> allows mobilization of a sufficient number of hematopoietic progenitors without impacting the efficacy of <scp>TCR<\/scp>\u2010alpha\/beta depletion in pediatric haploidentical and genoidentical donors failing to mobilize with <scp>G\u2010CSF<\/scp> alone"],"prefix":"10.1002","volume":"36","author":[{"given":"Elena","family":"Kurnikova","sequence":"first","affiliation":[{"name":"Dmitri Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology Ministry of Health of Russian Federation  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Trakhtman","sequence":"additional","affiliation":[{"name":"Dmitri Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology Ministry of Health of Russian Federation  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-7209","authenticated-orcid":false,"given":"Dmitry","family":"Pershin","sequence":"additional","affiliation":[{"name":"Dmitri Rogachev National Research Centre for Pediatric Hematology, Oncology and Immunology Ministry of Health of Russian Federation  Moscow 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