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SPG is a rare but severe complication of disseminated intravascular coagulation (DIC) and is frequently associated with sepsis. The pathophysiology of SPG includes DIC\u2010mediated intravascular thrombosis and thrombotic occlusion of microcirculation, resulting in low blood flow. Sepsis\u2010induced hypotension has been suspected as one of the other causes of SPG, and it is thought to be aggravated by vasopressor treatments given for hypotension. Our patient first experienced coldness, paleness, and cyanosis in his body's acral parts, and then SPG later developed in both his feet and hands. Septic shock management was performed with cytokine hemoadsorption, broad\u2010spectrum antibiotics, and massive fluid replacement rapidly. The patient fully recovered without the need for amputation. Hemoadsorption is an extracorporeal cytokine\u2010adsorption method for removing excess cytokines. Prompt management of septic shock and early monitoring of peripheral ischemia are essential to avoid SPG.<\/jats:p>","DOI":"10.1002\/jca.21893","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:32:47Z","timestamp":1616495567000},"page":"649-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recovery of Symmetrical Peripheral Gangrene of Limbs in a Patient After Performing Hemoadsorption in Septic Shock"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-9519","authenticated-orcid":false,"given":"Bahar","family":"Uncu Ulu","sequence":"first","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Center Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-8882","authenticated-orcid":false,"given":"Tu\u011f\u00e7e Nur","family":"Yi\u011feno\u011flu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Center Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Hac\u0131bekiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Hematology Sakarya University Hospital  Sakarya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dursun Ali","family":"Sa\u011flam","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences  Ankara 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