{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:11Z","timestamp":1789609091776,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007163","name":"Therakos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007163","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study assessed pharmacoeconomic costs associated with extracorporeal photopheresis (ECP) compared with other available second\u2010line therapies for chronic graft\u2010vs\u2010host disease (cGvHD) in a tertiary Spanish institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (\u226518\u2009years) diagnosed with steroid\u2010refractory cGvHD were eligible. Data were collected retrospectively from index date until 1\u00a0year or relapse. Patients were distributed in two cohorts (ECP vs non\u2010ECP), matched by age (\u2264 or\u2009&gt;\u200940), hematopoietic stem cell transplant (HLA\u2010identical sibling donor or other) and number of previous immunosuppressive lines (1, 2, or\u2009\u2265\u20093). Costs were assigned using the 2016 diagnosis\u2010related group (DRG) system: DRG 579 (\u20ac22\u2009383) overnight stay due to major complication (ie, sepsis, pneumonia, parenteral nutrition, or respiratory failure), and DRG 875 (\u20ac5154) if no major complication. The primary endpoint was healthcare resource utilization per patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients (n\u00a0=\u00a020 per cohort) were included. Median age was 49, and 37.5% were female. Mean total cost per patient was \u20ac25\u2009319 (95% CI: \u20ac17 049\u2013\u20ac33 590) across the two cohorts, with a slightly lower mean cost per ECP\u2010treated patient (\u20ac23\u2009120) compared with the non\u2010ECP cohort (\u20ac27\u2009519; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.597). Twenty\u2010seven inpatient hospitalizations occurred among ECP\u2010treated patients, vs 33 in the non\u2010ECP cohort. Day hospital and external consultations were more frequent in the ECP cohort. However, fewer inpatient admissions included DRG 579 compared with the non\u2010ECP cohort (44% vs 58%). Inpatient length of stay was slightly shorter in the ECP cohort (30 vs 49\u2009days; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.298).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ECP treatment may yield economic savings in Spain through resource savings and moving costs toward outpatient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21901","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T07:50:50Z","timestamp":1620546650000},"page":"612-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Extracorporeal photopheresis vs standard therapies for steroid\u2010refractory chronic graft\u2010vs\u2010host disease: Pharmacoeconomic assessment of hospital resource use in Spain"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-5561","authenticated-orcid":false,"given":"Blanca","family":"Boluda","sequence":"first","affiliation":[{"name":"Haematology Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-3878","authenticated-orcid":false,"given":"Antonio","family":"Solana\u2010Altabella","sequence":"additional","affiliation":[{"name":"Pharmacy Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Hematology Research Group Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cano","sequence":"additional","affiliation":[{"name":"Haematology Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Hematology Research Group Instituto de 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