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While Waldenstr\u00f6m's macroglobulinemia accounts for 80% to 90% of cases, HVS may develop in other clinical settings characterized by elevations in plasma proteins. Limited evidence currently exists describing the safety and efficacy of therapeutic plasma exchange (TPE) for the management of HVS secondary to non\u2010neoplastic conditions. We report a case of recurrent HVS associated with juvenile rheumatoid arthritis and Felty syndrome that demonstrated improvement in clinical symptoms following initiation of TPE. These findings suggest that TPE may be utilized as an adjunct treatment option in patients with HVS secondary to autoimmune disorders.<\/jats:p>","DOI":"10.1002\/jca.21903","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:34:47Z","timestamp":1620142487000},"page":"658-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The utility of therapeutic plasma exchange in Hyperviscosity syndrome associated with juvenile rheumatoid arthritis: A case report"],"prefix":"10.1002","volume":"36","author":[{"given":"Allen P.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Pathology, Division of Transfusion Medicine and Hemostasis University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pathology, 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