{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:43:17Z","timestamp":1791895397098,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rheopheresis is a double\u2010filtration plasmapheresis that removes high\u2010molecular\u2010weight molecules from the plasma and thereby lowers blood viscosity. This treatment has been proposed in hemodialysis (HD) patients for chronic limb\u2010threatening ischemia (CLTI), but very few studies have evaluated the usefulness of this technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principal Objective<\/jats:title><jats:p>To assess 1\u2010year amputation\u2010free survival (AFS) of HD patients suffering from CLTI treated by rheopheresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Method<\/jats:title><jats:p>We conducted a retrospective study of 28 consecutive HD patients treated by rheopheresis in three French dialysis centers between 1 February 2017 and 30 April 2019 in two indications resulting from CLTI, namely chronic ulceration or recent minor amputation with delayed healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010year AFS rate reached 53.6 (\u221219.8;\u2009+16.3)%. One\u2010year overall survival rate reached 67.9 (\u221220.5;\u2009+13.1)%. Main causes of death were infections and related to palliative care implying reduction or withdrawal of regular dialysis treatment. Hypotension episodes were the main rheopheresis adverse events with a prevalence rate of 13.5%. Rheopheresis sessions significantly reduced fibrinogen, C\u2010reactive protein, \u03b12\u2010macroglobulin, total cholesterol, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, triglycerides, IgM, and estimated plasma viscosity (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rheopheresis may improve clinical outcomes of CLTI in HD patients. The assessment of rheopheresis effectiveness needs to be confirmed by a multicenter randomized controlled trial, such as the ongoing project in France (RHEO\u2010PAD, NCT: 03975946).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21955","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T13:49:54Z","timestamp":1638884994000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rheopheresis for severe peripheral arterial disease in hemodialysis patients: A clinical series"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-3329","authenticated-orcid":false,"given":"Justine","family":"Solignac","sequence":"first","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation H\u00f4pital de la Conception, CHU de Marseille  Marseille France"},{"name":"Aix Marseille Universit\u00e9, INSERM, INRAE, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Bataille","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, INRAE, C2VN  Marseille France"},{"name":"Phocean Nephrology Institute, Clinique Bouchard, ELSAN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Touzot","sequence":"additional","affiliation":[{"name":"Centre of Dialysis Association pour utilisation du rein artificiel dans la r\u00e9gion parisienne (AURA) Saint Joseph, H\u00f4pital de Paris Saint Joseph, CHU de Paris V  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Bruner","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, INRAE, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dammar","family":"Bouchouareb","sequence":"additional","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation H\u00f4pital de la Conception, CHU de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brunet","sequence":"additional","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation H\u00f4pital de la Conception, CHU de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ridel","sequence":"additional","affiliation":[{"name":"Centre of Dialysis Association pour utilisation du rein artificiel dans la r\u00e9gion parisienne (AURA) Saint Joseph, H\u00f4pital de Paris Saint Joseph, CHU de Paris V  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-0913","authenticated-orcid":false,"given":"Thomas","family":"Robert","sequence":"additional","affiliation":[{"name":"Centre of Nephrology and Renal Transplantation H\u00f4pital de la Conception, CHU de Marseille  Marseille France"},{"name":"Service de n\u00e9phrologie et transplantation, APHM, H\u00f4pital de la Conception  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.02.340"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05600515"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.06.203"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.2436"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.206"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.09.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716688073"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000259"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.3.836"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487316672004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2010-1312"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007053230106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2000.004005348.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-1992-12409"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2005.00276.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703001010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.12.048"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.05.019"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04387.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107477"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.2.205"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.21955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:36:13Z","timestamp":1693002973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jca.21955"],"URL":"https:\/\/doi.org\/10.1002\/jca.21955","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}