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Due to severe presentation and recent ingestion of high plasma protein binding medication with long half\u2010life, therapeutic plasma exchange (TPE) was performed and resulted in full neurological recovery. This case explores the role of TPE as an effective treatment option for life\u2010threatening cyclobenzaprine overdose. TPE is generally beneficial for drugs that have a low volume of distribution and high plasma protein binding. Cyclobenzaprine is known to have a relatively high volume of distribution. However, in the case of drug intoxication with relatively high\u2010volume distribution, high protein binding, and long half\u2010life, TPE could be effective if it is conducted promptly.<\/jats:p>","DOI":"10.1002\/jca.21960","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T11:04:43Z","timestamp":1640430283000},"page":"313-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange"],"prefix":"10.1002","volume":"37","author":[{"given":"Cihangir","family":"Buyukgoz","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care Medicine The University of Tennessee Health Science Center\/Le Bonheur Children's hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantaveer","family":"Gangu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine The University of Tennessee Health Science Center\/Le Bonheur Children's hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faaria","family":"Gowani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The University of Tennessee Health Science Center\/Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Apheresis Service Le Bonheur Children's Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-8506","authenticated-orcid":false,"given":"Dai","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine The University of Tennessee Health Science Center\/Le Bonheur Children's hospital  Memphis Tennessee USA"},{"name":"Apheresis Service Le Bonheur Children's Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.FCH.0000347986.44810.59"},{"volume-title":"StatPearls","year":"2021","author":"Khan I","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/281392"},{"volume-title":"Flexeril (Cyclobenzaprine HCl) Tablets","year":"2001","key":"e_1_2_6_5_1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01033.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002462"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.01030.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00989-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20185"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.21960","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.21960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:45:39Z","timestamp":1692877539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.21960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,25]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/jca.21960"],"URL":"https:\/\/doi.org\/10.1002\/jca.21960","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"type":"print","value":"0733-2459"},{"type":"electronic","value":"1098-1101"}],"subject":[],"published":{"date-parts":[[2021,12,25]]},"assertion":[{"value":"2021-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}