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Despite this significant reduction, contamination of autologous cellular therapy products remains a challenging issue, as many of these mitigation strategies are not feasible for such products. Most microorganisms isolated from cellular therapy products are Gram\u2010positive normal skin flora, and studies have demonstrated that adverse effects are infrequent when these contaminated products are infused. However, no prior report has documented an autologous hematopoietic stem cell (HSC) or other cellular therapy product contaminated with <jats:italic>Salmonella<\/jats:italic> bacteria\u2014a pathogenic Gram\u2010negative organism. We present the first known case of <jats:italic>Salmonella<\/jats:italic> contaminating an HSC product secondary to occult salmonellosis in the donor, and discuss the implications of this contaminating organism and the therapeutic dilemma posed by this scenario.<\/jats:p>","DOI":"10.1002\/jca.21962","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T11:18:53Z","timestamp":1640431133000},"page":"316-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Autologous hematopoietic stem cell product contaminated with <i>Salmonella<\/i> due to occult salmonellosis in an asymptomatic donor"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-9685","authenticated-orcid":false,"given":"Jeremy W.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Guarente","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-3132","authenticated-orcid":false,"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-2245","authenticated-orcid":false,"given":"Christopher A.","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noffar","family":"Bar","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine and Yale Cancer Center Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010018\u20102212\u20109"},{"key":"e_1_2_7_3_1","unstructured":"EBMT.8th Edition of the FACT\u2010JACIE Standards;2021.https:\/\/www.ebmt.org\/8th-edition-fact-jacie-standards. 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