{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T07:48:13Z","timestamp":1714463293751},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematopoietic stem cells (HPCs) donors mobilized by granulocyte\u2010colony\u2010stimulating factor (G\u2010CSF) can develop various signs and symptoms. proBNP (pro\u2010B\u2010type natriuretic peptide) is a serum marker of heart failure. A donor who developed severe adverse reactions after G\u2010CSF mobilization was found to have high serum proBNP levels. We followed additional donors who received identical mobilization regimen to investigate the prevalence of this phenomenon. Eighteen healthy donors underwent a mobilization regimen of 10\u00a0\u03bcg\/Kg G\u2010CSF daily for 5\u2009days prior to allogeneic HPC collection using Spectra Optia between January 2016 and February 2017 were included in this study. Serum proBNP levels were measured before and after G\u2010CSF stimulation and immediately after apheresis. Apheresis collection parameters and other laboratory results were also reviewed. The majority of donors (86.7%) had post\u2010G\u2010CSF elevation of serum proBNP. Seven of those had elevated proBNP above upper normal range (124\u2009pg\/ml). The subgroup of donors with normal proBNP is younger (median age of 37 vs 42\u2009years), with majority being male (90.9% vs 28.6%) and with smaller processed blood volume (2.2 vs 3 \u00d7 total blood volume). This case series demonstrates an increase of serum proBNP can be common in HPC donors stimulated with 5\u2009days of 10 mcg\/kg G\u2010CSF. This is an adverse reaction that has not been described before. The temporary elevation of proBNP in these donors is not associated with ventricular dysfunction of the heart. The risk factors for marked elevation of proBNP post\u2010G\u2010CSF should be further investigated.<\/jats:p>","DOI":"10.1002\/jca.21979","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T07:58:25Z","timestamp":1647590305000},"page":"354-359","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased serum <scp>pro\u2010B\u2010type<\/scp> natriuretic peptide in hematopoietic progenitor cell donors stimulated with <scp>G\u2010CSF<\/scp>"],"prefix":"10.1002","volume":"37","author":[{"given":"Leonard N.","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Montemayor\u2010Garcia","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario 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