{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:41:23Z","timestamp":1780605683260,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic immune\u2010inflammatory biomarkers (SIIBs) have not been studied in mycosis fungoides (MF) patients undergoing extracorporeal photopheresis (ECP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to determine whether recently proposed SIIBs are suitable to predict ECP treatment outcome and overall prognosis of patients with MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine MF patients were retrospectively evaluated who had undergone ECP. SIIBs included neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, lymphocyte\u2010to\u2010monocyte ratio, and pan\u2010immune\u2010inflammation value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lymphocyte count (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021), CD4+\/CD8+ cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.00006), CD4+\/CD56+ NK cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.00008), and LDH levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0041) significantly declined after 6\u2010month ECP. We could not detect significant cutoff values for baseline SIIBs capable of predicting advanced disease, overall response to 6\u2010month ECP, or 5\u2010year lymphoma\u2010specific (LS) survival (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Circulating baseline counts of CD4+\/CD7\u2010 cells (cutoff: \u2264\u200912.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010) and CD4+\/CD26\u2010 cells (cutoff: \u2264\u200919.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) significantly predicted ECP treatment response after 6\u00a0months. Moreover, CD4+\/CD8+ ratio (cutoff: &gt;\u20091.34; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045) and increased thrombocyte counts (cutoff: &gt;259\u2009000; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010) were baseline predictors for 5\u2010year LS death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ECP appears to be beneficial in early\u2010stage CTCL as well. Lower percentages of circulating CD4+\/CD7\u2010 and CD4+\/CD26\u2010 lymphocytes at baseline correlate with response to ECP. In this study, however, baseline SIIBs did not appear to serve as suitable biomarkers for the prediction of treatment outcome and LS survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.21982","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T08:31:41Z","timestamp":1648629101000},"page":"360-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of extracorporeal photopheresis in mycosis fungoides patients is not predicted by quotients of systemic immune\u2010inflammatory biomarkers"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7862-3695","authenticated-orcid":false,"given":"Thilo","family":"Gambichler","sequence":"first","affiliation":[{"name":"Skin Cancer Center, Department of Dermatology Ruhr\u2010University Bochum  Bochum 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