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The diagnosis is difficult because of its various clinical presentations, nonetheless is extremely important due to the mortality rate. We describe a 14\u2010year\u2010old boy who developed hypersensitivity to either teicoplanin or meropenem therapy. After failing to improve with corticosteroids, he was successfully treated with therapeutic plasma exchange (TPE). TPE should be considered in the treatment with corticosteroid\u2010resistant DRESS syndrome.<\/jats:p>","DOI":"10.1002\/jca.21999","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:38:54Z","timestamp":1657881534000},"page":"600-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of severe <scp>DRESS<\/scp> syndrome treated with therapeutic plasma exchange and intravenous immunoglobulin therapy"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-8859","authenticated-orcid":false,"given":"Cansu","family":"Durak","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Intensive Care Unit, Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa  Istanbul 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