{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T23:08:31Z","timestamp":1774998511547,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic inflammatory myopathies (IIMs) encompass many rheumatologic diseases characterized by inflammatory muscle disease, typically unified by proximal muscle weakness. A subset of patients with IIM present with interstitial lung disease (ILD) with identifiable antibodies such as in anti\u2010synthetase syndrome (AS) with antibodies to aminoacyl\u2010tRNA synthetases, and clinically amyopathic dermatomyositis (CADM) with anti\u2010melanoma differentiation\u2010associated protein 5 (MDA5). Recent case reports demonstrate response to therapeutic plasma exchange (TPE) or column filtration plasmapheresis in IIM with ILD resistant to medical management. We present our experience with eight patients with IIM with ILD undergoing TPE at a large US\u2010based hospital system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient characteristics<\/jats:title><jats:p>Eight patients with IIM with ILD were treated with TPE over the last 10\u2009years. The therapy consisted of 5\u20107 one plasma volume exchanges every other day to daily. Seven of eight patients had identifiable antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following completion of TPE, seven of eight demonstrated improvement in pulmonary function despite lack of improvement of pulmonary function with standard therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In antibody\u2010mediated, treatment refractory IIM with ILD, TPE may be a viable intervention. This is a disease for which the role of apheresis is evolving.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>Not application.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.22034","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:47:10Z","timestamp":1669027630000},"page":"481-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic plasma exchange for steroid refractory idiopathic inflammatory myopathies with interstitial lung disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-6357","authenticated-orcid":false,"given":"Thomas Zachary","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Minnesota  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1597-8071","authenticated-orcid":false,"given":"Aleh","family":"Bobr","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin Eddie","family":"Juskewitch","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Minnesota  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-3732","authenticated-orcid":false,"given":"Jeffrey Lawrence","family":"Winters","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Minnesota  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24566"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep375"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0246-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00012-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.1.1019"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/304177a0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0176-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.069237"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-827-0_11"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00014707"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0119-8"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"9","article-title":"Recent treatment of interstitial lung disease with idiopathic inflammatory myopathies","volume":"9","author":"Kawasumi H","year":"2015","journal-title":"Clin Med Insights Circ Respir Pulm Med"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00239"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0433-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21387"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.09.082"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21833"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21824"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1121-18"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0297-17"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21815"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv068"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0622-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2928-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa123"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","unstructured":"SasakiN IshiiA ShimuraK et al.Efficacy of early initiation of plasma exchange therapy for a patient with anti\u2010MDA5 autoantibody\u2010positive dermatomyositis developing refractory rapidly progressive interstitial lung disease. 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