{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:16:21Z","timestamp":1747149381723,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006432","name":"Terumo BCT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006432","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For the past 30\u2009years, white blood cell depletion (WBCD) or leukocytapheresis has been conducted to rapidly reduce excessive circulating white blood cell (WBC) concentrations in patients at risk for or with symptoms of leukostasis due to hyperleukocytosis. The goal of leukocytapheresis is to prevent or treat acute complications from leukostasis, thereby enabling patients to receive potentially curative chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This report details the results from a retrospective and a prospective clinical study conducted in the European Union and the People's Republic of China, which assessed the use of the Spectra Optia Apheresis System for leukocytapheresis in patients with hyperleukocytosis. The primary objective of both studies was to the assess the safety and performance of the WBCD procedure in patients with elevated WBC counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from 72 participants completing 87 WBCD procedures. The mean percent change in participant WBC counts post\u2010procedure was 50.3\u2009\u00b1\u200921.2% and the collection efficiency (CE1) of the WBCD procedures was 53.7\u2009\u00b1\u200919.8%. Sixty\u2010one participants (95.3%) experienced a total of 279 adverse events (AEs) with the majority of the AEs related to post\u2010procedure changes in laboratory values, which is an anticipated AE in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data collected within these studies indicate that the WBCD procedure is safe and well tolerated in patients with hyperleukocytosis as evaluated by percent decrease in WBC count, CE1, and AE incidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.22038","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:01:43Z","timestamp":1674111703000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and performance of the<scp>S<\/scp>pectra<scp>O<\/scp>ptia apheresis system for white blood cell depletion in patients with elevated white blood cell counts"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-7832","authenticated-orcid":false,"given":"Pamela","family":"Lopert","sequence":"first","affiliation":[{"name":"Terumo BCT, Inc. Lakewood Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohair","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Terumo BCT, Inc. Lakewood Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Graybill","sequence":"additional","affiliation":[{"name":"Terumo BCT, Inc. Lakewood Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Terumo BCT, Inc. Lakewood Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"Dierickx","sequence":"additional","affiliation":[{"name":"UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine and Immunohaematology German Red Cross Blood Donor Service Baden\u2010W\u00fcrttemberg\u2010Hessen gGmbH Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marienn","family":"Reti","sequence":"additional","affiliation":[{"name":"Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases Szent Laszla Hospital Campus Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Depei","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Wuhan Union Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligen","family":"Liu","sequence":"additional","affiliation":[{"name":"Tongren Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"The Second People\u2019s Hospital of Shenzhen Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Bill","sequence":"additional","affiliation":[{"name":"Terumo BCT, Inc. 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