{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:00:38Z","timestamp":1776765638612,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Liver transplant is a life\u2010saving treatment, but due to the limited availability of suitable liver donors, ABO\u2010incompatible liver transplants (ABOi\u2010LT) are conducted to increase the availability of liver donors. Perioperative desensitization for ABOi\u2010LT is an established strategy to circumvent the risk of graft rejection. A single prolonged session can be performed to achieve the desired titers to avoid using multiple immunoadsorption (IA) columns or off\u2010label reuse of single\u2010use columns. This study retrospectively assessed the effectiveness of a single prolonged plasmapheresis session using IA as a desensitization strategy in live donor liver transplant (LDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This retrospective observational study conducted at a center for liver diseases in North India on six ABOi\u2010LDLT patients who underwent single prolonged IA sessions in the perioperative period from January 2018 to June 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median baseline titer in patients was 320 (64, 1024). The median plasma volume adsorbed was 7.5 volumes (4, 8) per procedure, with a mean procedure time of 600\u2009min (310\u2010753). The reduction in titer ranged from 4 log to 7 log reduction per procedure. Two patients developed transient hypotension during the procedure, which was managed successfully. The median duration of pre\u2010transplant hospital stay was 1.5\u2009days (1, 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Desensitization therapy helps overcome the ABO barrier and decreases the waiting period before a transplant when ABO identical donors are unavailable. A single prolonged IA session reduces the cost of additional IA columns and hospital stay, thus making it a cost\u2010effective approach to desensitization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.22058","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:24:50Z","timestamp":1684301090000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Large volume plasmapheresis using a single\u2010use immunoadsorption column: A cost\u2010effective approach for desensitization in <scp>ABO<\/scp>\u2010incompatible liver transplant"],"prefix":"10.1002","volume":"38","author":[{"given":"Sarika","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-939X","authenticated-orcid":false,"given":"Ashish","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-7845","authenticated-orcid":false,"given":"Meenu","family":"Bajpai","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2019.1601720"},{"key":"e_1_2_10_3_1","volume-title":"Apheresis: principles and Practice","author":"McLeod BC","year":"2010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13644"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.08.007"},{"key":"e_1_2_10_7_1","first-page":"102","volume-title":"Spectra Optia Apheresis System Operator's Manual","year":"2018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493595"},{"key":"e_1_2_10_9_1","volume-title":"Guidelines for ABO incompatible transplantation","year":"2015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12215"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000110295.88926.5C"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13444"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Therapeutic apheresis in ABO\u2010 incompatible kidney and liver transplantation: a single center experience of 50 patients","volume":"25","author":"Pandey P","year":"2020","journal-title":"Ther Apher Dial"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.04.028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-1440-3-17"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/759581"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2019.05.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i3.548"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000457"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_373_19"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13502"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.22058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:29:41Z","timestamp":1697074181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.22058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jca.22058"],"URL":"https:\/\/doi.org\/10.1002\/jca.22058","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2022-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}