{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:15:43Z","timestamp":1787501743984,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The PLASMIC score was developed for distinguishing thrombotic thrombocytopenic purpura (TTP) from other types of thrombotic microangiopathy. However, two components of the PLASMIC score, mean corpuscular volume (MCV) and international normalized ratio (INR), showed non\u2010significant differences between TTP and non\u2010TTP patients in previous validations. Here, we validate the PLASMIC score and aim to modify it by adjusting the criteria of MCV and INR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective validation of suspected TTP patients was performed by reviewing electronic medical records from two medical centers in Taiwan. The performance of different modified types of the PLASMIC score was carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 50 patients included in the final analysis, 12 were diagnosed with TTP based on deficiency of ADAMTS13 activity and clinical judgement. When stratified by high (score\u2009\u2265\u20096) and low\u2010intermediate risk (score\u2009&lt;\u20096), the positive predictive value (PPV) of the PLASMIC score to predict TTP was 0.45 (95% confidence interval [CI]: 0.29\u20100.61). The area under curve (AUC) was 0.70 (95% CI: 0.56\u20100.82). When adjusting the criteria of the PLASMIC score from MCV\u2009&lt;\u200990\u2009fL to MCV\u2009\u2265\u200990\u2009fL, the PPV increased to 0.57 (95% CI: 0.37\u20100.75). The AUC was 0.75 (95% CI: 0.61\u20100.87). When adjusting the INR from &gt;1.5 to &gt;1.1, the PPV increased to 0.56 (95% CI: 0.39\u20100.71). The AUC was 0.81 (95% CI: 0.68\u20100.90).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCV\u2009\u2265\u200990\u2009fL and\/or INR\u2009&gt;\u20091.1 might be suitable modifications for PLASMIC score but should be validated in a larger sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jca.22068","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T04:50:57Z","timestamp":1686891057000},"page":"582-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A validation and modification of\n                    <scp>PLASMIC<\/scp>\n                    score by adjusting the criteria of mean corpuscular volume and international normalized ratio"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-807X","authenticated-orcid":false,"given":"Jia\u2010Arng","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hwa","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Kai","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Kwan Boris","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Anesthesiology China Medical University College of Medicine  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh\u2010Chyi","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei 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