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However, it can have unusual multiple end\u2010organ injuries including extrarenal organ and system involvements such as neurologic, cardiac, gastrointestinal, and respiratory systems. We describe a 4\u2010year\u2010old girl who developed aHUS due to the TSEN2 mutation and had cardiac involvement. She did not benefit from plasma exchange, as stated in previous cases. It should be kept in mind that therapeutic plasma exchange may not be beneficial in some cases of aHUS, especially due to genetic mutations.<\/jats:p>","DOI":"10.1002\/jca.22070","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T12:29:59Z","timestamp":1687264199000},"page":"647-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Why has plasma exchange failed in <scp>TRACK<\/scp> syndrome? 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