{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:40:04Z","timestamp":1777052404649,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemato\u2010oncologic patients receiving intensive chemotherapy may develop severe neutropenia and serious bacterial and\/or fungal infections. Granulocyte transfusions (GTs) may be beneficial as a bridging therapy in hemato\u2010oncologic patients with febrile neutropenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the clinical effectiveness of GTs in hemato\u2010oncologic patients with febrile neutropenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study evaluated the effectiveness of 150 GTs in 88 hemato\u2010oncologic patients. Donors were mobilized with granulocyte colony\u2010stimulating factors and dexamethasone. Patients' hematological parameters (pre\u2010 and post\u2010GT) and safety and effectiveness of GTs were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The safety and effectiveness of GTs were assessed in the patients with various underlying conditions, including 78% with acute myeloid leukemia. In total, 150 GTs were administered, mostly during the chemotherapy induction phase. The GTs were well\u2010tolerated by the patients, and a significant increment in white blood cell count and absolute neutrophil count (ANC) was noticed in 95% of patients after the transfusion. The granulocyte dose was positively correlated with ANC after the transfusion. The average time to neutrophil recovery from the last day of GT was 6.7\u2009days, and the 30\u2010day survival rate was 77%. The donors were all men, and a significant increase in WBC count was observed post\u2010mobilization. The median granulocyte yield was 2.28\u2009\u00d7\u200910\n                      <jats:sup>10<\/jats:sup>\n                      \/unit. All granulocyte products were crossmatched and irradiated before the transfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GTs can be a useful adjunctive treatment for febrile neutropenia in hemato\u2010oncologic patients with multidrug\u2010resistant sepsis. However, additional studies are required for confirming their effectiveness and establishing guidelines for their use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jca.22084","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T08:52:54Z","timestamp":1691657574000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Navigating the neutropenic abyss with granulocyte transfusions: Retrospective single\u2010center analysis of effectiveness and safety in India"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-8368","authenticated-orcid":false,"given":"Priti","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Tata Memorial Centre Homi Bhabha National Institute  Mumbai Maharashtra 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