{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:08:54Z","timestamp":1771254534643,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many factors were identified for mobilization failure (MF) in autologous hematopoietic stem\u2010cell transplantation. To our knowledge, this is the first study to investigate the efficacy of baseline inflammation indexes and neutrophil\u2010to\u2010lactate dehydrogenase (LDH) ratio to predict MF in multiple myeloma (MM) and lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 240 patients with lymphoma or MM hospitalized between January 2014 and June 2022 for the first stem cell mobilization were included in this retrospective single\u2010center study. We evaluated the impact of baseline demographic, clinical, and laboratory data (before granulocyte colony\u2010stimulating factor and chemotherapy implementation), including neutrophil, neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio, monocyte\u2010to\u2010lymphocyte ratio, systemic immune\u2010inflammation index (SII), systemic inflammatory response index (SIRI), neutrophil\u2010to\u2010C\u2010reactive protein, and neutrophil\u2010to\u2010LDH ratios on MF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 240 patients were divided into successful (214 patients, 89.16%) and poor mobilizers (26 patients, 10.84%). Poor mobilizers had lower neutrophil, NLR, SII, and neutrophil\u2010to\u2010LDH ratios (\n                      <jats:italic>P<\/jats:italic>\n                      values were .001, .022, .001, and .001, respectively). Among these markers, only the neutrophil\u2010to\u2010LDH ratio was statistically low in both poor mobilizer MM and lymphoma patients. Receiving operator characteristic curve analysis was performed to evaluate neutrophil, SII, and neutrophil\u2010to\u2010LDH ratios for MF. Neutrophil\u2010to\u2010LDH ratio had the highest specificity (93.93%, for \u22649.904 cut\u2010off) compared to the other two variables. Multivariate logistic regression analysis showed that neutrophil\u2010to\u2010LDH ratio \u2264\u20099.904 (cut\u2010off) (odds ratio: 7.116,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001), neutrophil counts \u22643300\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (cut\u2010off) (odds ratio: 3.248,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.021), and lymphoma diagnosis (odds ratio: 2.674,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.039) were independent risks for MF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The neutrophil\u2010to\u2010LDH ratio could be a novel marker in lymphoma and MM patients to predict the first MF. New studies should be conducted for the optimization of this index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jca.22085","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T03:04:50Z","timestamp":1691982290000},"page":"711-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline inflammation indexes and\n                    <scp>neutrophil\u2010to\u2010LDH<\/scp>\n                    ratio for prediction of the first mobilization failure without plerixafor\u2010based regimens in multiple myeloma and lymphoma patients: A single\u2010center retrospective study"],"prefix":"10.1002","volume":"38","author":[{"given":"Ahmet Burak","family":"Dirim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik Onur","family":"Tiryaki","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soner","family":"Altin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi Kalayoglu","family":"Besisik","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ipek Yonal","family":"Hindilerden","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meliha","family":"Nalcaci","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.69"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052638"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.07.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201006\u2010318220"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21400"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.03321.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705897"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704466"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-017-0051-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0442"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.882896"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.4.345"},{"issue":"11","key":"e_1_2_9_14_1","article-title":"Usefulness of complete blood count (CBC) to assess cardiovascular and metabolic diseases in clinical settings: a comprehensive literature review","volume":"10","author":"Seo IH","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S395331"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S283835"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.2736"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.10.2547"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.681042"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505737"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277\u20105379(82)90242\u20105"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.22085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.22085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.22085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T14:18:49Z","timestamp":1771251529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.22085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jca.22085"],"URL":"https:\/\/doi.org\/10.1002\/jca.22085","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]},"assertion":[{"value":"2023-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}