{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:20Z","timestamp":1789609100376,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A1046464"],"award-info":[{"award-number":["2021R1F1A1046464"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between leukapheresis (LK) as a treatment option for hyperleukocytosis (HL) in patients with acute myeloid leukemia (AML) remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were extracted from the electronic medical record for 2801 patients with AML between April 2009 and December 2019. LK was performed when the leukocyte count was \u2265100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L at the time initial bone marrow examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A comparison between the patients with HL in the non\u2010LK (n\u2009=\u20091579) and LK (n\u2009=\u2009208) groups revealed survival probabilities (%) of 93.2% and 90.4% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.130) for day 30 (D30), 85.4% and 84.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.196) for D60, and 83.6% and 80.8% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.258) for D90, respectively. After propensity score matching, a comparison between the patients with HL in the non\u2010LK (n\u2009=\u2009192) and LK (n\u2009=\u2009192) groups revealed survival probabilities (%) of 83.9% and 91.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.030) for D30, 75.0% and 84.9% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.015) for day 60 (D60), and 62.4% and 81.3% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.034) for day 90 (D90), respectively. After D150, the observed effect of LK appeared to be mitigated without a survival benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>LK was associated with improved early survival outcomes at D30, D60, and D90 among patients with AML exhibiting HL. Thus, it may be considered a treatment option for reducing cell mass in such patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jca.22090","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:15:33Z","timestamp":1696310133000},"page":"727-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of leukapheresis on early survival in acute myeloid leukemia: An observational propensity score matching cohort study"],"prefix":"10.1002","volume":"38","author":[{"given":"Howon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Ho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeeun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Suk","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine, Apheresis Unit Seoul St. 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