{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:02:42Z","timestamp":1784048562914,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371821"],"award-info":[{"award-number":["81371821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this retrospective study is to compare the efficacy and safety of the centrifugal separation therapeutic plasma exchange (TPE) using citrate anticoagulant (cTPEc) with membrane separation TPE using heparin anticoagulant (mTPEh) in liver failure patients. The patients treated by cTPEc were defined as cTPEc group and those treated by mTPEh were defined as mTPEh group, respectively. Clinical characteristics were compared between the two groups. Survival analyses of two groups and subgroups classified by the model for end\u2010stage liver disease (MELD) score were performed by Kaplan\u2013Meier method and were compared by the log\u2010rank test. In this study, there were 51 patients in cTPEc group and 18 patients in mTPEh group, respectively. The overall 28\u2010day survival rate was 76% (39\/51) in cTPEc group and 61% (11\/18) in mTPEh group (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). The 90\u2010day survival rate was 69% (35\/51) in cTPEc group and 50% (9\/18) in mTPEh group (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). MELD score\u2009=\u200930 was the best cut\u2010off value to predict the prognosis of patients with liver failure treated with TPE, in mTPEh group as well as cTPEc group. The median of total calcium\/ionized calcium ratio (2.84, range from 2.20 to 3.71) after cTPEc was significantly higher than the ratio (1.97, range from 1.73 to 3.19) before cTPEc (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). However, there was no significant difference between the mean concentrations of total calcium before cTPEc and at 48\u2009h after cTPEc. Our study concludes that there was no statistically significant difference in survival rate and complications between cTPEc and mTPEh groups. The liver failure patients tolerated cTPEc treatment via peripheral vascular access with the prognosis similar to mTPEh. The prognosis in patients with MELD score\u2009&lt;\u200930 was better than in patients with MELD score\u2009\u2265\u200930 in both groups. In this study, the patients with acute liver failure (ALF) and acute on chronic liver failure (ACLF) treated with cTPEc tolerated the TPE frequency of every other day without significant clinical adverse event of hypocalcemia with similar outcomes to the mTPEh treatment. For liver failure patients treated with cTPEc, close clinical observation and monitoring ionized calcium are necessary to ensure the patients' safety.<\/jats:p>","DOI":"10.1002\/jca.22103","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T07:14:33Z","timestamp":1702624473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A single center retrospective study: Comparison between centrifugal separation plasma exchange with <scp>ACD\u2010A<\/scp> and membrane separation plasma exchange with heparin on acute liver failure and acute on chronic liver failure"],"prefix":"10.1002","volume":"39","author":[{"given":"Xin\u2010Fang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Transfusion Huashan Hospital, Fudan University  Shanghai 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Infectious Diseases and Biosafety Emergency Response Huashan Hospital, Fudan University  Shanghai China"},{"name":"Liver Diseases Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Transfusion Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Mei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Transfusion Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2010Kang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital, Fudan University  Shanghai China"},{"name":"National Medical Center for infectious diseases  China"},{"name":"Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response Huashan Hospital, Fudan University  Shanghai China"},{"name":"Liver Diseases Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital, Fudan University  Shanghai China"},{"name":"National Medical Center for infectious diseases  China"},{"name":"Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response Huashan Hospital, Fudan University  Shanghai 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University  Shanghai China"},{"name":"Liver Diseases Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital, Fudan University  Shanghai China"},{"name":"National Medical Center for infectious diseases  China"},{"name":"Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response Huashan Hospital, Fudan University  Shanghai China"},{"name":"Liver Diseases Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital, Fudan University  Shanghai China"},{"name":"National Medical Center for infectious diseases  China"},{"name":"Shanghai Key Laboratory of Infectious Diseases and Biosafety 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