{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:43:16Z","timestamp":1791895396977,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010five HD patients affected by <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> Lerich\u00e8\u2010Fontaine and ischemic ulcer <jats:styled-content style=\"fixed-case\">1C<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">2C<\/jats:styled-content> according to the University of Texas Wound Classification System (<jats:styled-content style=\"fixed-case\">UTWCS<\/jats:styled-content>), without amelioration after traditional medical therapy and\/or revascularization, were selected and underwent 12 Rheopheresis sessions in 10\u2009weeks. Improvements in pain symptoms using Numerical Rating Scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>), healing ulcers and laboratory hemorheological parameters have been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A clinically and statistically significant mean value reduction and of relative percentage differences between estimated marginal means (\u0394), calculated at each visits, of NRS was observed, with a maximum value (\u221248.5%) between the first and last visit. At the end of the treatment period 14.3% of ulcers were completely healed, 46.4% downgraded, 53.6% were stable. Overall, no ulcers upgraded. A statistically significant reduction of the \u0394, between the first and last visit, for fibrinogen (\u221216%) was also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rheopheresis reduced overall painful symptoms; data suggest that it could heal or improve ulcers and hemorheological laboratory parameters in HD patients with PAD and ischemic ulcers resistant to standard therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jca.22132","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:34:47Z","timestamp":1722940487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-2065","authenticated-orcid":false,"given":"Claudia","family":"Altobelli","sequence":"first","affiliation":[{"name":"Department of Critical Area, Nephrology and Dialysis Unit Cotugno Hospital \u2013 AORN Ospedali dei Colli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Carone","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Department of Economics, Management and Statistics University Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Anastasio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Pluvio","sequence":"additional","affiliation":[{"name":"Department of Critical Area, Nephrology and Dialysis Unit Cotugno Hospital \u2013 AORN Ospedali dei Colli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"de Pascale","sequence":"additional","affiliation":[{"name":"Department of Critical Area, Nephrology and Dialysis Unit Cotugno Hospital \u2013 AORN Ospedali dei Colli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Vernaglione","sequence":"additional","affiliation":[{"name":"\u201cA. 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