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The etiological, prognostic and predictive role of the Ab anti\u2010PLA2R is demonstrated. Standard therapy consists in anti\u2010CD20 monoclonal antibody rituximab (RTX) combined with steroids or immunosuppressants according to the risk of progressive loss of kidney function. The immunosuppressive therapies are potentially associated to severe adverse events that lead to protocol suspension. Given their pivotal pathogenetic role, serum clearance of anti\u2010PLA2R with plasmapheresis could have a beneficial impact on NS, particularly in patients not requiring or tolerating standard therapies. In this series, we present three cases of PMN anti\u2010PLA2R related treated with a RTX plus plasmapheresis approach and demonstrate its overall effective role on anti\u2010PLA2R titer and clinical outcomes.<\/jats:p>","DOI":"10.1002\/jca.22134","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T12:10:01Z","timestamp":1719490201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic plasmapheresis in idiopathic membranous nephropathy anti\u2010PLA2R\u2010related: A case series"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0101","authenticated-orcid":false,"given":"Dario","family":"Musone","sequence":"first","affiliation":[{"name":"UOC Nefrologia e Dialisi  Formia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Nicosia","sequence":"additional","affiliation":[{"name":"UOC Nefrologia e 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