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An elevated pretreatment ratio of CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> T lymphocytes fell to subnormal. The beneficial results of treatment may be attributed to the reduction of lymphocyte populations responsible for IgE production by the combined action of plasmapheresis and of cytotoxic drugs as well as the direct effect of removal of circulating IgE and possibly IgE\u2010potentiating factors.<\/jats:p>","DOI":"10.1002\/jca.2920040104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T15:08:18Z","timestamp":1172070498000},"page":"8-12","source":"Crossref","is-referenced-by-count":10,"title":["Remission of hyper\u2010lgE syndrome treated with plasmapheresis and cytotoxic immunosuppression"],"prefix":"10.1002","volume":"4","author":[{"given":"Peter C.","family":"Dau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1001\/archderm.1969.01610250018004","article-title":"Immunogiobuiin E in dermatoses: Levels in atopic dermatitis and urticaria","volume":"100","author":"Juhlin L","year":"1969","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/archderm.1971.04000180001001","article-title":"IgE in atopic dermatitis","volume":"103","author":"Ogawa M","year":"1971","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1001\/archderm.1973.01620200030006","article-title":"IgE in atopic dermatitis and other common dermatoses","volume":"107","author":"Gurevkch AW","year":"1973","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676481"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620270032008"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2340\/0001555554193202","article-title":"Immunoglobuiins in atopic dermatitis: with special reference to IgE","volume":"54","author":"Ohman S","year":"1974","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.112.9.1254"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb02185.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.225.4.378"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198307000-00001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1976.tb04922.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1001\/archderm.1976.01630340005001","article-title":"Infection, dermatitis, increased IgE, and impaired neutrophii chemotaxis: A possible relationship","volume":"112","author":"Dahl MV","year":"1976","journal-title":"Arch Dertnatol"},{"key":"e_1_2_1_14_2","first-page":"640","article-title":"Neutrophii chemotaxis in wo patients with recurrent staphylococcal skin infections and hyperimmunoglobulin E","volume":"92","author":"Issekutz AC","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1069043"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/archderm.1976.01630340009002","article-title":"Immunodeficiencies in severe atopic dermatitis: Depressed chemotaxis and lymphocyte transformation","volume":"112","author":"Rogge JL","year":"1976","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-1-39"},{"key":"e_1_2_1_18_2","first-page":"295","article-title":"Plasma exchange in a patient with by per IgH syndrome","volume":"49","author":"Ishikawa I","year":"1982","journal-title":"Ann Allergy"},{"key":"e_1_2_1_19_2","first-page":"65","article-title":"Case report. 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