{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T13:27:00Z","timestamp":1768051620964,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":6161,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the bilirubin reduction capacity of three different types of devices in vitro: a high\u2010permeable membrane column for double\u2010filtration plasmapheresis (DFP) (Evaflux 2A, Kuraray, Japan), and non\u2010coated charcoal column for hemoperfusion (HP) (N\u2010180, Asahi Medical, Japan), and ion\u2010exchange columns for plasma adsorption (PA) (BR\u2010350, Asahi Medical, Japan, and B\u2010001, Kuraray, Japan). A column for DFP reduced the concentration of lowmolecular proteins effectively such as plasma bilirubin and bile acids in an albumin\u2010dependent manner. A charcoal column adsorbed low\u2010molecular substances preferentially. But in these two columns, the loss of fibrinogen is a limiting factor for determining the processing plasma volume. Ion\u2010exchange columns for PA adsorbed bile acids, disconjugated bilirubin, and monoconjugated bilirubin more efficiently compared with delta\u2010bilirubin and unconjugated bilirubin. Pretreatment of the column with heparin reduced the loss of fibrinogen to less than 10%. We applied the BR\u2010350 ion\u2010exchange column in vivo for treatment of three patients with hyperbilirubinemia. After treatment, an alcoholic hepatitis patient with the hepatorenal syndrome (HRS) recovered from acute renal failure. However, in a patient with primary biliary cirrhosis and in a patient with fulminant hepatitis, the decrease of serum bilirubin was transient and no obvious beneficial responses were noted. The capacity and ability of the BR\u2010350 column to adsorb plasma bilirubin was shown sufficient to treat deeply jaundiced patients, because 4 liters of the plasma of a patient with 108 mg\/dl of initial total bilirubin concentration was able to be processed continuously without an obvious decrease in bilirubin adsorption capacity. Therefore, this column in combination with dialysis may be most applicable in lowering serum bilirubin concentration in the HRS.<\/jats:p>","DOI":"10.1002\/jca.2920050302","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T15:54:11Z","timestamp":1172073251000},"page":"123-127","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of bilirubin clearance capacity of a newly developed ion\u2010exchange adsorption column and its possible use as a supportive therapy in hepatorenal syndrome"],"prefix":"10.1002","volume":"5","author":[{"given":"Jun","family":"Sone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiji","family":"Saibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Himeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutake","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keunsik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshika","family":"Okumiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105679"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92115-9"},{"key":"e_1_2_1_4_2","first-page":"320","article-title":"The influence of dietary protein intake on specific renal functions in normal man","volume":"44","author":"Pullman TN","year":"1954","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301203080318"},{"key":"e_1_2_1_6_2","first-page":"328","article-title":"Effects upon plasma glucagon on infused and ingested amino acids and of protein meals in man","volume":"18","author":"Pek S","year":"1969","journal-title":"Diabetes"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90268-3"},{"key":"e_1_2_1_8_2","first-page":"822","article-title":"Determinants of deranged sodium and water homeostasis in decompensated cirrhosis","volume":"87","author":"Epstein M","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80073-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90435-1"},{"key":"e_1_2_1_11_2","first-page":"33","volume-title":"\u201cLiver Injury.\u201d Transactions of the 6th Conference","author":"Shorr E","year":"1947"},{"key":"e_1_2_1_12_2","first-page":"133","volume-title":"The Kidney in Liver Disease","author":"Wilkinson SP","year":"1978"},{"key":"e_1_2_1_13_2","first-page":"87","volume-title":"The Kidney in Liver Disease","author":"Papper S","year":"1983"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5386.810"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83732-9"},{"key":"e_1_2_1_16_2","first-page":"570","article-title":"A liver kidney syndrome. 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