{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:12:18Z","timestamp":1773303138146,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":5796,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracorporeal procedures for selective removal of low\u2010density lipoproteins have become a promising new approach for treatment of severe familial hypercholesterolemia. We tested efficacy and safety of a new LDL apheresis system by using two dextran sulfate cellulose adsorbents (Liposorber LA 15<jats:sup>TM<\/jats:sup> from Kanegafuchi) under the control of an automatic column\u2010regenerating unit for continuous alternate adsorption and desorption. Plasma was taken from a continuous\u2010flow blood cell separator (model IBM\/Cobe 2997) allowing an extracorporeal circuit from one cubital vein to another. A 57\u2010year\u2010old male with drug\u2010resistant heterozygous familial hypercholesterolemia accompanied by moderate hypertriglyceridemia and severe coronary artery disease has been treated every 2 weeks for 3 months so far. Treatment of 4\u20135 liters of plasma resulted in a mean decrease of total cholesterol from 355 to 111 mg\/dl (9.20 to 2.88 mmol\/l), of LDL cholesterol from 272 to 49 mg\/dl (7.05 to 1.53 mmol\/l), and of apolipoprotein B from 175 to 44 mg\/dl. HDL cholesterol, apolipoprotein A\u2010I, and other plasma proteins did not substantially change apart from hemodilution. No side effects were seen. This new technique of LDL apheresis represents a very effective and safe method for treatment of drug\u2010resistant familial hypercholesterolemia without or with concomitant hypertri\u2010lyceridemia.<\/jats:p>","DOI":"10.1002\/jca.2920060103","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T15:48:44Z","timestamp":1172072924000},"page":"11-15","source":"Crossref","is-referenced-by-count":12,"title":["Application of a new LDL apheresis system using two dextran sulfate cellulose columns in combination with an automatic column\u2010regenerating unit and a blood cell separator"],"prefix":"10.1002","volume":"6","author":[{"given":"W.","family":"Knisel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Besenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Di","family":"Nicuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rebstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Risler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eggstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"672","volume-title":"The Metabolic Basis of Inherited Disease","author":"Goldstein JL","year":"1983"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(86)90146-0"},{"issue":"1","key":"e_1_2_1_4_2","first-page":"1\u2010152","article-title":"Plasmapheresis in familial hypercholesterolemia","volume":"9","author":"Thompson GR","year":"1989","journal-title":"Arteriosclerosis"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.6.613"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920040204"},{"key":"e_1_2_1_7_2","first-page":"17","article-title":"Erfahrungen mit dem Analysensystem \u201cMonitor Parallel\u201d. I. Methodik und Organisation","volume":"8","author":"Liebich HM","year":"1985","journal-title":"GIT Labor\u2010Medizin"},{"key":"e_1_2_1_8_2","first-page":"101","article-title":"Erfahrungen mit dem Analysensystem \u201cMonitor Parallel\u201d. II","volume":"8","author":"Liebich HM","year":"1985","journal-title":"Evaluation GIT Labor\u2010Medizin"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92193-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91213-7"},{"key":"e_1_2_1_11_2","first-page":"590a","article-title":"Comparison of two LDL\u2010apheresis systems for treatment of severe hypercholesterolemia (abstract)","volume":"8","author":"Knisel W","year":"1988","journal-title":"Arteriosclerosis"},{"key":"e_1_2_1_12_2","first-page":"447","article-title":"Selective removal of lowdensity lipoprotein (LDL) by plasmapheresis combined with selective plasma protein ultrafiltration (SPU)","volume":"4","author":"von Baeyer H","year":"1983","journal-title":"Plasma Ther Transfus Technol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728226"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/039139888600900517","article-title":"Adsorption of lipoprotein containing apolipoprotein\u2010B through plasma separation for treatment of familial hypercholesterolemia","volume":"9","author":"Odaka M","year":"1986","journal-title":"Int J Artif Organs"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(86)90083-3"},{"key":"e_1_2_1_16_2","first-page":"55","article-title":"Selektive Elimination atherogener Lipoproteine mit Dextransulfat\u2010Cellulose","volume":"119","author":"Riesen WF","year":"1989","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90089-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb00032.x"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.2920060103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.2920060103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:44:30Z","timestamp":1698047070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.2920060103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/jca.2920060103"],"URL":"https:\/\/doi.org\/10.1002\/jca.2920060103","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}