{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:08Z","timestamp":1760188868429},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":4700,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>OBJECTIVE: To explore the potential efficacy of plasma exchange as an ancillary interventive therapeutic tool immediately before or after delivery in the patient with severe preeclampsia\/eclampsia and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. STUDY DESIGN: Two gravidas with complicated severe preeclampsia\/eclampsia\/HELLP syndrome were treated emergently in the immediate peripartal period with single\u2010volume plasma exchange and fresh frozen plasma fluid replacement using the IBM 2997 Cell Separator. RESULTS: Despite multiple platelet unit infusions, one primigravida in active labor at 5 cm cervical dilatation and 39 weeks' gestation remained at a platelet count of 14,000\/\u03bcL and began to ooze from her gums. A second primigravida remained obtunded, oliguric, and thrombocytopenic with epistaxis and hematuria following cesarean delivery and platelet transfusions. A single expedited 3\u2010liter plasma exchange procedure reversed the rapidly deteriorating clinical situation for each patient and accelerated recovery from HELLP syndrome. Both patients and progeny suffered no permanent sequelae. CONCLUSION: Based on our experience, we believe that the therapeutic modality of plasma exchange with fresh frozen plasma can be employed effectively for the pregnant patient with severe atypical HELLP syndrome that progressively worsens during labor or the early puerperium despite the use of conventional transfusion therapy.<\/jats:p>","DOI":"10.1002\/jca.2920090303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T16:05:05Z","timestamp":1172073905000},"page":"162-165","source":"Crossref","is-referenced-by-count":22,"title":["Plasma exchange for preeclampsia: III. Immediate peripartal utilization for selected patients with hellp syndrome"],"prefix":"10.1002","volume":"9","author":[{"suffix":"Jr.","given":"James N.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Kenneth G.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe C.","family":"Files","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia F.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela G.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32330-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90266-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199011000-00001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91429-Z"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999540"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292763"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0889-8545(21)00266-7","article-title":"Care of the pregnancy complicated by HELLP syndrome","volume":"18","author":"Barton JR","year":"1992","journal-title":"Obstet Gynecol Clin North Am"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0889-8545(21)00267-9","article-title":"Imitators of preeclampsia and HELLP syndrome","volume":"18","author":"Martin JN","year":"1991","journal-title":"Obstet Gynecol Clin North Am"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0002-9378(12)90962-X","article-title":"Analysis of 454 pregnancies with severe preeclampsia\/eclampsia and HEELP syndrome: Comparative analysis using the Mississippi classification system","volume":"168","author":"Martin JN","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_11_2","unstructured":"RobertsWE PerryKGJr WoodsJB FilesJC BlakePG MartinJNJr:The intrapartum platelet count in HELLP syndrome patients: Is it predictive of later hemorrhagic complications?Am J Obstet Gynecol in press."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90835-U"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jca.2920090302","article-title":"Plasma exchange for preeclampsia. II. Unsuccessful antepartum utilization for severe preeclampsia with or without HELLP syndrome","volume":"9","author":"Martin JN","journal-title":"J Clin Apheresis"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1980.tb00773.x"},{"key":"e_1_2_1_15_2","first-page":"143","article-title":"Treatment of eclampsia by plasma exchange","volume":"2","author":"Kris M","year":"1981","journal-title":"Plasma Therapy"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000182212"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.20.2808"},{"key":"e_1_2_1_18_2","first-page":"205","article-title":"Treatment of severe preeclampsia in the third trimester by plasma exchange","volume":"4","author":"Baylis MS","year":"1983","journal-title":"Plasma Therap Transfus Technol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920010204"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/08860228309076046"},{"key":"e_1_2_1_21_2","first-page":"53S","article-title":"Severe preeclampsia with persistent postpartum hemolysis and thrombocytopenia treated by plasmapheresis","volume":"65","author":"Schwartz ML","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_22_2","first-page":"136","article-title":"Possible role for exchange plasmapheresis with fresh frozen plasma for maternal indications in selected cases of preeclampsia and eclampsia","volume":"67","author":"Schwartz ML","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994683"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920070102"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1993.tb02374.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15172.x"},{"key":"e_1_2_1_27_2","unstructured":"MagannEF BassD ChauhanSP SullivanDL MartinRW MartinJNJr:Antepartum corticosteroids: Disease stabilization in patients with HELLP syndromeAm J Obstet Gynecol in press."},{"key":"e_1_2_1_28_2","unstructured":"MagannEF WashburneJF SullivanCA NormanPF SchorrSJ MartinJNJr:Corticosteroid arrest of HELLP syndrome progression in a marginally\u2010viable pregnancy. Am J Obstet Gynecol in press."}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjca.2920090303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.2920090303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:41:04Z","timestamp":1698108064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.2920090303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/jca.2920090303"],"URL":"https:\/\/doi.org\/10.1002\/jca.2920090303","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}