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However, secondary loss of response (LOR) to these agents, due to anti\u2010drug antibodies, poses a significant therapeutic challenge. This report describes a case where granulocyte and monocyte adsorptive apheresis (GMA) maintenance therapy successfully restored the efficacy of an anti\u2010TNF\u2010\u03b1 agent in a 26\u2010year\u2010old male with active UC experiencing LOR to infliximab. Following GMA induction therapy and continued infliximab administration, clinical symptoms improved, fecal calprotectin levels decreased, and clinical remission was achieved. Long\u2010term maintenance with GMA enabled sustained clinical remission, with mucosal healing observed one year post\u2010therapy. This case suggests that GMA maintenance therapy may serve as a novel therapeutic approach for patients with active UC experiencing LOR to anti\u2010TNF\u2010\u03b1 agents. However, further studies are warranted to elucidate the underlying mechanisms and validate its efficacy.<\/jats:p>","DOI":"10.1002\/jca.70030","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:25:28Z","timestamp":1746188728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Granulocyte and Monocyte Adsorptive Apheresis Maintenance Therapy Restored the Loss of Response to Anti\u2010<scp>TNF<\/scp>\u2010Alpha Agents in the Patients With <scp>UC<\/scp>: A Case Report"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-4766","authenticated-orcid":false,"given":"Nobuhiro","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of General Medicine Asahikawa Medical University Hospital  Asahikawa Hokkaido Japan"},{"name":"Department of Gastroenterological Sciences Asahikawa Medical University  Asahikawa Hokkaido 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