{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:02Z","timestamp":1756370402928,"version":"3.44.0"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the case of a 50\u2010year\u2010old male with peripheral T\u2010cell lymphoma who underwent allogeneic hematopoietic stem cell transplantation and developed overlap chronic graft\u2010versus\u2010host disease (ocGvHD) requiring extracorporeal photopheresis (ECP). His clinical presentation included a maculopapular rash with jaundice, hepatosplenomegaly, hyperbilirubinemia, and elevated liver enzymes. Liver biopsy findings were not consistent with GvHD or lymphoma but were suggestive of drug\u2010induced hepatitis. ECP was initiated using the Therakos CellEx Photopheresis System. During the initial sessions, dark green plasma discoloration was observed, accompanied by multiple plasma\/red blood cell interface\u2010related procedural alarms. These challenges were managed through various operator adjustments, and the procedures remained safe and effective. Over four ECP sessions, both the discoloration and opacity of the plasma progressively improved, in parallel with declining liver enzyme levels and a reduction in procedural alarms. This temporal association between hepatic recovery and improved interface stability during ECP has not been previously described in the context of ocGvHD. Although dark green plasma is an uncommon finding in this setting, it should prompt evaluation for underlying hepatic dysfunction and timely management of plasma\/red blood cell interface issues to ensure safe and effective ECP delivery.<\/jats:p>","DOI":"10.1002\/jca.70045","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T05:13:53Z","timestamp":1752210833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Plasma in Extracorporeal Photopheresis: A Case Report in Overlap Chronic <scp>GvHD<\/scp>"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8169-9914","authenticated-orcid":false,"given":"Yandy Marx","family":"Castillo\u2010Aleman","sequence":"first","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3256-2783","authenticated-orcid":false,"given":"Aseel Suleiman","family":"Alsaid","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9490-9878","authenticated-orcid":false,"given":"Shinnette","family":"Lumame","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6316-9717","authenticated-orcid":false,"given":"Charisma","family":"Castelo","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3727-586X","authenticated-orcid":false,"given":"Jay Mary Rose","family":"Roque","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5631-322X","authenticated-orcid":false,"given":"Marlene","family":"Cato","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7080-764X","authenticated-orcid":false,"given":"Yara Khaled","family":"Afifi","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-6176","authenticated-orcid":false,"given":"Sheima","family":"Ali","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-9269","authenticated-orcid":false,"given":"Mohamed Ibrahim","family":"Abu\u2010Haleeqa","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3375-5674","authenticated-orcid":false,"given":"Inas","family":"El\u2010Najjar","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"},{"name":"College of Medicine and Health Sciences (UAE University)  Abu Dhabi UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6773-8099","authenticated-orcid":false,"given":"Nameer","family":"Al\u2010Saadawi","sequence":"additional","affiliation":[{"name":"Abu Dhabi Stem Cells Center (ADSCC)  Abu Dhabi UAE"},{"name":"Yas Clinic Khalifa City (YCKC), Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702997"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196907242810407"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2005.00189.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_117_18"},{"key":"e_1_2_8_6_1","unstructured":"Therakos CellEx Photopheresis System Operator's Manual for Use with Software 5.4. 1470526\u2010Rev03\u2010ENG\u2010UK \u201cECP Procedure With the CELLEX\u00ae System \u201d 2019."}],"container-title":["Journal of Clinical 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