{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:51Z","timestamp":1773032511725,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160801"],"award-info":[{"award-number":["82160801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute\u2010on\u2010chronic liver failure (ACLF) is the most prevalent type of liver failure in Asia, with hepatitis B virus (HBV) infection being the primary cause in our country. This study aimed to evaluate the effectiveness of the artificial liver support system (ALSS) in treating HBV\u2010induced ACLF (HBV\u2010ACLF) and assess the efficacy and safety of a combined ALSS model with small\u2010volume plasma. A retrospective analysis compared the 4\u2010week and 12\u2010week survival rates of patients receiving comprehensive medical treatment versus ALSS treatment and identified factors associated with mortality. Patients undergoing the combined ALSS model (plasma exchange\u2009+\u2009double plasma adsorption system\/hemoperfusion, PE\u2009+\u2009DPMAS\/HP) were categorized into small\u2010volume plasma and half\u2010volume plasma groups. Changes in liver function, renal function, coagulation function, and blood ammonia levels following PE\u2009+\u2009DPMAS\/HP treatment were analyzed. Mortality rates at 4 and 12\u2009weeks were compared between the two groups, and factors influencing 4\u2010week and 12\u2010week mortality in HBV\u2010ACLF patients were examined. The results indicated no significant difference in 4\u2010week mortality between the ALSS and medical treatment groups; however, the ALSS group showed a significantly improved 12\u2010week survival rate. Both small\u2010volume and half\u2010volume plasma ALSS models effectively eliminated bilirubin, bile acids, urea, and creatinine. No significant differences were observed in 4\u2010week and 12\u2010week mortality between the small\u2010volume and half\u2010volume plasma groups, regardless of the severity of HBV\u2010ACLF (early, middle, or late stages). COX proportional hazard regression analysis revealed that the amount of plasma used in ALSS treatment was not a significant factor influencing HBV\u2010ACLF prognosis. The combined ALSS model with reduced plasma usage may help alleviate the limited plasma supply and merits further application and promotion.<\/jats:p>","DOI":"10.1002\/jca.70058","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:00:48Z","timestamp":1770872448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Combined Plasma Exchange With Plasma Adsorption\/Hemoperfusion Artificial Liver Support System (\n                    <scp>ALSS<\/scp>\n                    ) in Treating Acute\u2010on\u2010Chronic Liver Failure due to Hepatitis B"],"prefix":"10.1002","volume":"41","author":[{"given":"Dingchun","family":"Li","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Duan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruidong","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Chao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"38","article-title":"Guidelines for the Diagnosis and Treatment of Liver Failure (2018 Edition)","volume":"35","author":"Failure L","year":"2019","journal-title":"Journal of Clinical Hepatobiliary Diseases"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i16.4745"},{"issue":"10","key":"e_1_2_10_4_1","first-page":"772","article-title":"Analysis of the Etiology and Prognosis of 1977 Patients With Acute, Subacute, and Acute\u2010On\u2010Chronic Liver Failure","volume":"16","author":"Liu X. 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