{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:07:50Z","timestamp":1780546070620,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Naphthalene toxicity is a rare but serious cause of methemoglobinemia and hemolysis, particularly in patients with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, in whom methylene blue is contraindicated. We present a case of a 6\u2010year\u2010old girl with a family history of G6PD deficiency who developed cyanosis, jaundice, dark urine, and an oxygen saturation of 50% after ingesting a mothball. Laboratory findings confirmed hemolytic anemia with suspected methemoglobinemia. Methylene blue was avoided, and initial treatment with high\u2010flow oxygen, ascorbic acid, and N\u2010acetylcysteine failed to improve her condition. Red blood cell exchange (RCE) was performed, leading to rapid normalization of oxygen saturation and resolution of hemolysis. G6PD deficiency was later confirmed by enzyme assay. We concluded that in G6PD\u2010deficient children with naphthalene\u2010induced methemoglobinemia, RCE provides an effective alternative to methylene blue, resulting in rapid recovery.<\/jats:p>","DOI":"10.1002\/jca.70070","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T09:49:57Z","timestamp":1763545797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Red Blood Cell Exchange for Naphthalene\u2010Induced Methemoglobinemia in a Child With Glucose\u20106\u2010Phosphate Dehydrogenase Deficiency: A Case Report"],"prefix":"10.1002","volume":"40","author":[{"given":"Hanan Hassan","family":"El\u2010sheity","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Menoufia University  Shebin Elkom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagwan Yossery","family":"Saleh","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine Menoufia University  Shebin Elkom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shady Mohamed","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine Menoufia University  Shebin Elkom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Zaki","family":"Badawy","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Menoufia University  Shebin Elkom Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"13","article-title":"Naphthalene Mothballs: Emerging and Recurring Issues and Their Relevance to Environmental Health","volume":"7","author":"Sudakin D. L.","year":"2011","journal-title":"Current Topics in Toxicology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2000.tb01889.x"},{"issue":"8","key":"e_1_2_11_4_1","first-page":"1","article-title":"Naphthalene Poisoning Following Ingestion of Mothballs: A Case Report","volume":"9","author":"Kundra T. S.","year":"2015","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"11","key":"e_1_2_11_5_1","first-page":"740","article-title":"Severe Haemolytic Anaemia due to Ingestion of Naphthalene (Mothball) Containing Coconut Oil","volume":"22","author":"Rahman M.","year":"2012","journal-title":"Journal of the College of Physicians and Surgeons\u2013Pakistan"},{"issue":"8","key":"e_1_2_11_6_1","article-title":"Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular Hemolysis","volume":"10","author":"Volney G.","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6580.155379"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1305110"},{"issue":"8","key":"e_1_2_11_9_1","first-page":"e298","article-title":"Acute Naphthalene Poisoning Following the Non\u2010Accidental Ingestion of Mothballs","volume":"50","author":"Lim H. C.","year":"2009","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-215102"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.220858"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:52:36Z","timestamp":1780545156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jca.70070"],"URL":"https:\/\/doi.org\/10.1002\/jca.70070","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70070"}}