{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:10:52Z","timestamp":1780546252532,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human serum albumin (HSA) solution is widely used as a replacement fluid during therapeutic plasma exchange (TPE). However, the ionic concentrations in commercially available 5% HSA solutions differ significantly from physiological levels. In this study, we developed a simple method for preparing a replacement fluid with ion concentrations closer to physiological norms by mixing 25% HSA with lactated Ringer's solution, sodium chloride, and calcium gluconate hydrate. We prepared three types of replacement fluids, each with a 4.0% albumin concentration and total volumes of 1.83, 2.43, and 3.04\u2009L, and confirmed their compositional stability for up to 48\u2009h. Compared with the standard 5% HSA solution, the prepared fluids had calcium, sodium, potassium, and chloride levels more closely aligned with physiological values. Using HSA\u2010based replacement fluids with preadjusted electrolyte concentrations may help reduce the risk of imbalances, such as hypocalcemia, during TPE.<\/jats:p>","DOI":"10.1002\/jca.70077","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:30:01Z","timestamp":1764221401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Refinement of Replacement Fluid Using Human Serum Albumin Preparation to Enhance Biocompatibility in Therapeutic Plasma Exchange"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-249X","authenticated-orcid":false,"given":"Yuki","family":"Narita","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto Japan"},{"name":"Department of Pharmacy Kumamoto University Hospital  Kumamoto Japan"},{"name":"Faculty of Pharmaceutical Sciences Sojo University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Takegawa","sequence":"additional","affiliation":[{"name":"Immune inflammation &amp; Hematology Group, Medical Affairs Section, R&amp;D Administration Division KM Biologics Co. Ltd.  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Immune inflammation &amp; Hematology Group, Medical Affairs Section, R&amp;D Administration Division KM Biologics Co. Ltd.  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuji","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Center Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-8188","authenticated-orcid":false,"given":"Hirotoshi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Immune inflammation &amp; Hematology Group, Medical Affairs Section, R&amp;D Administration Division KM Biologics Co. Ltd.  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Sojo University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto Japan"},{"name":"Department of Pharmacy Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kumamoto University Graduate School of Medical  Kumamoto Japan"},{"name":"Kidney Disease and Dialysis Center Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22043"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14479"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103675"},{"issue":"1","key":"e_1_2_12_6_1","first-page":"79","article-title":"The Osmotic Pressure and Electrolyte Composition in Various Albumin Solutions Used as Replacement Fluids in Plasma Exchange","volume":"40","author":"Sakurasawa T.","year":"2021","journal-title":"Japanese Journal of Apheresis"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"155","article-title":"Development and Evaluation of a Setting Manual for Replacement Fluids in Plasma Exchange and Selective Plasma Exchange in the Medical Hospital of Tokyo Medical and Dental University","volume":"38","author":"Sejima T.","year":"2019","journal-title":"Japanese Journal of Apheresis"},{"key":"e_1_2_12_8_1","volume-title":"Guidelines for Clinical Laboratory Testing JSLM2021","author":"Society J.","year":"2021"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.017"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010025\u201003970\u20102"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20142"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010007\u20100549\u20104"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21473"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010023\u201003560\u2010x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/nrl.0000000000000430"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.17085\/apm.21045"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.1022"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.5649\/jjphcs.36.10"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070138"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc353"}],"container-title":["Journal of Clinical Apheresis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jca.70077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jca.70077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:53:02Z","timestamp":1780545182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jca.70077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jca.70077"],"URL":"https:\/\/doi.org\/10.1002\/jca.70077","archive":["Portico"],"relation":{},"ISSN":["0733-2459","1098-1101"],"issn-type":[{"value":"0733-2459","type":"print"},{"value":"1098-1101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70077"}}