{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:24:13Z","timestamp":1787239453990,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21TR004694\u201001A1"],"award-info":[{"award-number":["1R21TR004694\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD103083"],"award-info":[{"award-number":["K12HD103083"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The postpartum period represents a high\u2010risk interval for presentation with a pregnancy\u2010associated thrombotic microangiopathy (TMA). Given the possibility of immune thrombotic thrombocytopenic purpura, postpartum TMA is typically treated with initiation of therapeutic plasma exchange (TPE). Yet, TPE use in postpartum TMA and its impact on maternal outcomes are poorly understood. Therefore, this study sought to determine the incidence of TPE\u2010treated postpartum TMA and its impacts on maternal outcomes. In a retrospective cohort analysis of the Nationwide Readmission Database, we first identified patients with an index delivery hospitalization and then identified any readmissions within 30\u2009days. Readmissions were categorized according to TMA status (no TMA vs. postpartum TMA). Postpartum TMA readmissions were identified using validated International Classification of Diseases codes for TMA (M31.1) and TPE (6A550Z3 and 6A551Z3). We then estimated the national incidence of postpartum TMA readmissions and the risk of the primary composite outcome of mortality, thrombosis, and major bleeding. Among 11\u2009378\u2009671 delivery hospitalizations, we identified 41 postpartum TMA readmissions (incidence 3.6\/1\u2009000\u2009000 deliveries). Compared to non\u2010TMA readmissions, postpartum TMA readmissions were associated with higher rates of the composite outcome (26.8% vs. 4.7%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Postpartum TMA readmissions were also associated with higher rates of thrombosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), major bleeding (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and mortality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Although rare, postpartum TMA is associated with poor maternal outcomes. Future studies should explore strategies to improve outcomes in this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1002\/jca.70090","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:26:14Z","timestamp":1768533974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postpartum Readmission for Pregnancy\u2010Associated Thrombotic Microangiopathy Is Associated With Poor Maternal Outcomes"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-1249","authenticated-orcid":false,"given":"Alexandre","family":"Soares Ferreira Junior","sequence":"first","affiliation":[{"name":"Department of Medicine Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto  S\u00e3o Paulo Brazil"},{"name":"General and Applied Biology Program, Institute of Biosciences (IBB), Sao Paulo State University  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanduan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana","family":"Pinheiro Maux Lessa","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gordee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Sanborn","sequence":"additional","affiliation":[{"name":"Duke Biostatistics, Epidemiology and Research Design Core Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maragatha","family":"Kuchibhatla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-9853","authenticated-orcid":false,"given":"Allison O.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-6280","authenticated-orcid":false,"given":"Jerome Jeffrey","family":"Federspiel","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Division of Hematology, Department of Medicine Duke University School of Medicine  Durham North Carolina USA"},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatoyosi A.","family":"Onwuemene","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.05.016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005221"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1343060"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000290"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070706"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.022"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001186"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1692-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.04.009"},{"key":"e_1_2_12_11_1","unstructured":"\u201cOverview of the 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