{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:44Z","timestamp":1773032504984,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Apheresis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Thrombotic thrombocytopenic purpura (TTP) is a life\u2010threatening condition where prompt diagnosis and timely therapy are essential for improving patient outcomes. Previous studies have suggested that weekend hospital admissions may be associated with limited resources, leading to worse clinical outcomes. Given ongoing advancements in healthcare infrastructure, we aimed to re\u2010evaluate the impact of weekend admissions and hospital characteristics on TTP mortality. We conducted a retrospective cohort study using the National Inpatient Sample (NIS) database from 2016 to 2019. A chi\u2010squared test was applied to compare demographics (age, sex, racioethnic group), hospital\u2010related factors (bed size, region, location), primary payer type, income quartiles, Mortality in Thrombotic Thrombocytopenic Purpura Score (MITS), time to initiation of therapeutic plasma exchange (TPE) between weekday and weekend admissions. Logistic regression analysis was used to identify predictors of in\u2010hospital mortality while adjusting for covariates. Among 3725 hospitalizations, 68% of patients were female, 43.5% were white, and 20.8% belonged to the 50\u201359 age group. In\u2010hospital mortality was 6.2%. Patients who died had higher odds of being white (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), admitted to small or medium bed\u2010size hospitals (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), having higher MITS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and having longer time to TPE initiation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Multivariable regression analysis showed no significant association between the day of admission (weekday vs. weekend) and mortality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.35). While weekend hospital admission did not impact mortality, resource limitations in smaller hospitals may contribute to poor outcomes, as hospital bed size was a significant predictor of mortality. Addressing these disparities through targeted interventions could help optimize patient care and reduce mortality rates in TTP.\n                  <\/jats:p>","DOI":"10.1002\/jca.70093","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:14:20Z","timestamp":1770873260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Day of Hospital Admission and Hospital Characteristics on Mortality in Thrombotic Thrombocytopenic Purpura"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-0849","authenticated-orcid":false,"given":"Sri Prathima","family":"Kanneganti","sequence":"first","affiliation":[{"name":"Department of Research and Innovation Danbury Hospital, Northwell Health  Danbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishan Babu","family":"Pokhrel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Norwalk Hospital, Northwell Health  Norwalk Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabasha","family":"Weeraddana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Danbury Hospital, Northwell Health  Danbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Sostin","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation Danbury Hospital, Northwell Health  Danbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Thrombotic Thrombocytopenic Purpura","author":"Stanley M. 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